By the early 1990s, the amyloid cascade hypothesis had emerged, proposing that AD is fundamentally caused by deposition of Aβ protein. The cascade component of the hypothesis captures the idea ...

A hypothesis which has been the standard way of explaining how the body develops Alzheimer’s Disease for almost 30 years is flawed, according to a University of Manchester biologist. The ‘Amyloid ...

It appears that a second cascade, the tau cascade ... These studies validate both the amyloid hypothesis and the therapeutic approach of Aβ plaque removal; and yet we know the story is much ...

According to the amyloid cascade hypothesis, accumulation of beta-amyloid leads to the subsequent cascade of events ultimately resulting in the development of clinical symptoms of Alzheimer’s ...

The amyloid cascade hypothesis, on which many modern Alzheimer's treatments are based, presumes that these fibrils are the cause of the disease. However, emerging evidence suggests that amyloid ...

Current thinking, according to the amyloid cascade hypothesis, posits that β-amyloid—a fragment cleaved by enzymes called secretases from the larger amyloid precursor protein—begins to form ...

The work challenges the widely accepted amyloid cascade hypothesis, which suggests that beta-amyloid is the main driver of ...

This perspective challenges the amyloid cascade hypothesis, which identifies beta-amyloid as the main driver of the disease. By shifting attention to tau pathology, the findings could inspire the ...