cAMP is a major intracellular signalling mediator that directly affects the activity of cyclic-nucleotide-dependent protein kinases and gated ion channels. PDE4 represents an attractive target for ...

This high-resolution structure will provide valuable mechanistic insights into the interpretation of functional data. 2. Normal and inverse agonism in cyclic nucleotide-gated channels The "CNG" family ...

(Amgen). Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated channel blocker indicated to reduce the risk of hospitalization for worsening heart failure in adult patients with ...