and mutations in either of these genes leads to ineffective mismatch repair, failure to induce apoptosis, and cancer. Because mutations in hMSH2 or hMSH6 result in resistance to mutagens and DNA ...

Several cancer chemotherapy drugs work by producing excessive DNA damage that causes cell death directly or following DNA replication. Survival is promoted through repair of these lesions by a ...

Efficient DNA repair mechanisms are essential for ... and growth under adverse conditions. Downregulation of Mismatch Repair and Stress-Induced Mutagenesis Mismatch repair (MMR) is another pathway ...

During his undergraduate studies, he worked in the lab of Dr. Jennifer Surtees, where he investigated the contribution of DNA mismatch repair factors to trinucleotide repeat expansions. Maxwell joined ...

KL-50 was designed to fluoro-ethylate DNA bases, resulting in DNA inter-strand cross-links and subsequent DNA damage that triggers DNA mismatch repair (MMR)-independent apoptosis.

The study is designed to evaluate the safety, tolerability, and preliminary efficacy of ATX-559 in certain biomarker-selected cancer patients.