and the BRCA2 protein that binds to the resected ssDNA (Yang et al., 2002) and catalyzes the formation of the nucleoprotein filament by the RAD51 recombinase (Yang et al., 2005). View of an ...
In four of six cases, the recombination resulting in the duplication occurred between homologous chromosomes (interchromosomal). In one duplication patient (1353), the duplication was derived from ...
The search for DNA homology and formation of the junction between homologous regions is then carried out within the catalytic center of the filament. In addition to proteins that assist Rad51 ...
Common to these genomic integrity pathways is eventual repair by homologous recombination, a process that has been a longstanding focus of our research. The high-resolution views provided by ...
Homologous recombination is a high-fidelity ... by cohesins constrains the search locally, with cohesins being proteins that ...
This process requires a set of recombinases polymerized on single-stranded (ss) DNAs called the nucleoprotein filament to ...