uncoupling of oxidative phosphorylation (a mechanism to generate heat). However, drugs targeting these two reactions alone may not cause fat loss unless targeted to lower energy intake ...

Uncouplers stimulate electron transfer in conditions in which the rate of oxidation is limited by coupled phosphorylation. The precise mechanism of uncoupling is obscure.

Because reactive oxygen species are produced via oxidative phosphorylation during anaerobic ... that chronic oxidative stress is an important mechanism for glucose toxicity. Support for this ...