Summary: Duloxetine is a balanced selective serotonin and norepinephrine-reuptake inhibitor available in the United States for the treatment of major depressive disorder (MDD) and diabetic ...
In patients receiving serotonergic medications in combination with an MAOI, there have been reports of serious and sometimes fatal reactions, including hyperthermia, rigidity, myoclonus, autonomic ...
The most frequent 'class' effects seen with the two serotonin norepinephrine reuptake inhibitors (SNRIs—duloxetine and milnacipran) included nausea, headache, hyperhidrosis and constipation ...
SNRIs act on serotonin transporters (SERTs) and norepinephrine transporters (NETs), which are glycoproteins present in synapses. Their function is to take extra neurotransmitters from these ...