Growth, bone density, histology and fracture number are important outcome parameters, but are not simple to measure accurately and reproducibly in children with severe OI. For example, using ...

These include skeletal dysplasias, such osteogenesis imperfecta, and a spectrum of ... and this can contribute to the molecular pathology of the mutations. The emerging importance of ER stress ...

Osteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone fragility and low bone mass. Four clinical types are commonly distinguished. Schematically, type I is the mildest ...