RESULTS: 5-FU treatment for 24 hours resulted in S phase arrests, p53 accumulation, up-regulation of p53-target genes on DNA damage response (ATF3, GADD34, GADD45A, PCNA), cell cycle-regulatory ...

PCNA in its mutated form encourages tumours ... to selectively kills cancer cells by disrupting the normal cell reproductive cycle, but it did not interrupt the reproductive cycle of healthy ...

One such target is Chk1, the effector kinase responsible for activating the checkpoint and stalling the cell cycle ... polymerase, PCNA, and Claspin (Mrc1). These modifications alter protein ...