Dennis 4 described 2 children whose intussusception he attributed to polypoid hyperplasia of Peyer's patches in the terminal 2 cm. of ileum; both were treated by ileocecal resection, with recovery.

Specialized lymphoid tissue in the ileum, called Peyer’s patches, act as sites of B lymphocyte differentiation which leads to the production of pathogenic secretory IgA1 antibodies. In IgAN ...