CRT contains a cleavable signal sequence in this domain, which is found in proteins that are marked for targeting to the ER, and the presence of this signal indicates that CRT is transported into ...
The technological demand for bioconjugate chemistry is fueled by the exponential growth of pharma and biopharma. The protein targeting chemistry comprises varying aspects, including precision protein ...
Although great efforts have been made to address the bioavailability and tissue targeting of drugs ... trafficking from the plasma membrane to the ER followed by transfer to the nucleus 112.
We have identified the IRE1/XBP1 branch of the Unfolded Protein Response (UPR) or endoplasmic reticulum (EnR) stress response as a previously unexplored therapeutic vulnerability in MYC-driven breast ...
Auburn, AL – Researchers from Auburn University, partnering with the University of Basel in Switzerland, have discovered a new way to make a cancer-targeting protein complex more stable ...
This approach not only represents a significant advance in targeting transcription factors and disordered proteins, but also showcases the PLP technology's versatility and potential to ...
Amidst the wide variety of glycan modifications that are carried out in the Golgi apparatus, the addition of mannose 6-phosphate (M6P) to the N-linked glycans of lysosome-resident hydrolase enzymes ...
Vepdegestrant is an investigational, orally bioavailable PROTAC protein degrader designed to specifically target and degrade the estrogen receptor (ER) for the treatment of patients with ER positive ...