The physiology of serotonin is complex and involves synthesis, transport, reuptake and receptor activation 6. Circulating serotonin is produced in the duodenum by enterochromaffin cells ...
A surrogate test that may have clinical relevance is the duration of inhibition at 5-HT 3 receptors located on cutaneous afferent neurons. Intradermal injection of serotonin produces a flare ...
The theoretical basis for and clinical experience with using oral serotonin type 3 (5-HT 3)-receptor antagonists for preventing chemotherapy-induced emesis are discussed. Evidence supports the ...