Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for ...

Originally identified as a cell surface receptor that triggered the ... cell types in the immune system. Fas signaling may also be involved in T cell costimulation and proliferation.

Researchers developed SNIPRs, innovative receptors that sense soluble ligands, enabling precise therapeutic control in CAR ...

We found that interleukin 4 receptor (IL ... uses the IL-4R–STAT6 pathway. We confirmed this by IL-13 inhibitor (sIL-13Rα2–Fc) treatment. Loss of natural killer T cells (NKT cells) in CD1 ...

Campus Chemical Instrument Center, Mass Spectrometry & Proteomics Facility, The Ohio State University, Columbus, USA ...

The signaling pathway, which is mediated by the protein GP130, plays a central role in cell communication and influences the activity of the transcription factor STAT3, which in turn is associated ...

Immune cells are capable of detecting infections ... for example, when the receptor switches on a certain signaling pathway ...

Immune cells are capable of detecting infections just like a sniffer dog, using special sensors known as Toll-like receptors, or TLRs for short. But what signals activate TLRs, and what is the ...