Lipid nanoparticles (LNPs) transport small molecules into the body. The most well-known LNP cargo is mRNA, the key constituent of some of the early vaccines against COVID-19. But that is just one ...

Function-engineerable nanoparticles in combination with the advantageous effects of various functional lipid components enable achievement of enhanced blood stability, decreased toxicity and ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction ...

Their distinctive properties such as innate stability, low immunogenicity, biocompatibility, and excellent tissue or cell penetration capabilities allow them to function as superior natural ...

To address this issue, scientists have developed, and now widely use, the strategy of encapsulating mRNA into lipid nanoparticles (LNPs). Because LNPs protect mRNA, facilitate delivery to target ...

In this particular case, messenger ribonucleic acid (mRNA) encapsulated in lipid nanoparticles (LNPs) have been successfully manufactured, distributed and administered to populations throughout ...

Scientists from the University of Pennsylvania have developed an ideal “recipe” for ionizable lipids, which are essential components of lipid nanoparticles (LNPs), the molecules that underlie the ...

A new framework bridges a gap in understanding RNA therapeutics by linking the structure of lipid nanoparticles to immune ...

Researchers outline their improved lipid-polymer nanoparticle for holding mRNA that is stable when nebulized and successfully delivers aerosols (liquid droplets) into mice's lungs. mRNA medicines ...