NO development of organic chemistry or of biochemistry has unfolded in a more dramatic manner in recent years than that concerned with the nature and functions of the steroids, the bile acids ...

Whole body total cholesterol synthesis was not changed but bile-acid synthesis appeared to be stimulated, suggesting that KB2115 may act to induce net liver cholesterol removal. Previous studies ...

In hepatocytes, bile acids are secreted into bile canaliculi by bile salt export pump (BSEP), cholesterol is secreted by ATP binding cassette subfamily G member 5 (ABCG5) and ABCG8 heterodimer and ...