Researchers outline their improved lipid-polymer nanoparticle for holding mRNA that is stable when nebulized and successfully delivers aerosols (liquid droplets) into mice's lungs. mRNA medicines ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction ...

The recent success of the mRNA-LNP vaccines fueled biopharma to explore lipid-based nanoparticles for advanced drug delivery. The industry is now poised to exploit the full therapeutic potential ...

Scientists from the University of Pennsylvania have developed an ideal “recipe” for ionizable lipids, which are essential components of lipid nanoparticles (LNPs), the molecules that underlie the ...

Function-engineerable nanoparticles in combination with the advantageous effects of various functional lipid components enable achievement of enhanced blood stability, decreased toxicity and ...

School of Biomedical Engineering, University of British Columbia, Vancouver V6T 1Z3, Canada Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada School of Biomedical ...

2023 is set to be a landmark year for lipid-based delivery technology development and the 2nd Next-Generation Lipid-Based Nanoparticle Delivery Summit returns to unite 140+ biopharma thought ...

Lipid nanoparticles (LNPs) are primed to revolutionize the development of nucleic acid therapies. The trusted lipid experts at Cayman Chemical provide industry-leading solutions for every stage of LNP ...

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States David H Koch Institute for Integrative Cancer Research, Massachusetts Institute ...