KAP kinase-! may therefore mediate the inhibition of GSK3 by agonists which are much more potent activators of the classical MAP kinase pathway than is insulin.
Essential role for protein kinase B (PKB) in insulin-induced glycogen …
1998年5月22日 · Activation of phosphatidylinositide 3'-OH kinase (PI 3-kinase) is implicated in mediating a variety of growth factor-induced responses, among which are the inactivation of glycogen synthase kinase-3 (GSK-3) and the activation of the …
Insulin activates protein kinase B, inhibits glycogen synthase kinase …
1997年4月7日 · Insulin stimulated protein kinase B alpha (PKB alpha) more than 10-fold and decreased glycogen synthase kinase-3 (GSK3) activity by 50 +/- 10% in skeletal muscle and adipocytes. Rapamycin did not prevent the activation of PKB, inhibition of GSK3 or stimulation of glycogen synthase up to 5 min.
Requirement for Akt (Protein Kinase B) in Insulin-induced …
The roles of Akt (protein kinase B) and the atypical λ isoform of protein kinase C (PKCλ), both of which act downstream of phosphoinositide 3-kinase, in the activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1) in response to insulin were investigated.
Protein kinase B (PKB/Akt) – a key regulator of glucose transport?
2001年3月16日 · One of the first physiological targets of PKB to be identified was glycogen synthase kinase-3 (GSK3) [12], which has been implicated in the control of many cellular processes, including glycogen and protein synthesis, and the …
Essential Role for Protein Kinase B (PKB) in Insulin-induced Glycogen Synthase Kinase 3 Inactivation
Insulin activates protein kinase B, inhibits glycogen synthase kinase …
1997年4月7日 · Effect of rapamycin on the activation of p70 S6 kinase and glycogen synthase by insulin in skeletal muscle in vivo.
Glycogen synthase - Wikipedia
Glycogen synthase is directly regulated by glycogen synthase kinase 3 (GSK-3), AMPK, protein kinase A (PKA), and casein kinase 2 (CK2). Each of these protein kinases leads to phosphorylated and catalytically inactive glycogen synthase.
Essential Role for Protein Kinase B (PKB) in Insulin-induced Glycogen …
1998年5月22日 · Activation of phosphatidylinositide 3′-OH kinase (PI 3-kinase) is implicated in mediating a variety of growth factor-induced responses, among which are the inactivation of glycogen synthase kinase-3 (GSK-3) and the activation of the …
Insulin directly stimulates mitochondrial glucose oxidation in …
2020年12月7日 · Insulin stimulates mitochondrial protein kinase B (Akt), protein kinase C-delta (PKC-δ) and glycogen synthase kinase-3 beta (GSK-3β). Mitochondrial Akt plays a prerequisite role in mediating the activation of pyruvate dehydrogenase (PDH) and stimulation of cardiac glucose oxidation.
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