B-cell receptor - Wikipedia
The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor includes both CD79 and the immunoglobulin. The plasma membrane of a B cell is indicated by the green phospholipids. The B- cell receptor extends both outside the cell (above the plasma membrane) and inside the cell (below the membrane).
Structural principles of B cell antigen receptor assembly
2022年10月13日 · Our studies provide a structural platform for understanding B cell signalling and designing rational therapies against BCR-mediated diseases. B cells can recognize structurally diverse antigens,...
Cryo-EM structure of the human IgM B cell receptor | Science
2022年8月18日 · Here, we report the cryo–electron microscopy (cryo-EM) structure of VRC01-IgM-BCR (referred to as IgM-BCR hereafter) in complex with a Fab fragment of polatuzumab. An intact IgM-BCR consists of six chains: two heavy chains (μ), two light chains (κ), Igα, and Igβ.
A structural platform for B cell receptor signaling
2022年9月15日 · These findings explain the molecular principles underlying BCR assembly and provide opportunities for structure-guided rational engineering of BCRs for the treatment of hematological and...
Cryo-EM structures of two human B cell receptor isotypes
2022年8月18日 · We determined the cryo–electron microscopy (cryo-EM) structures of human IgG-BCR and IgM-BCR, which consist of membrane-bound immunoglobulin molecules (mIg) and Igα/β subunits at a 1:1 stoichiometry. Assembly of both BCR complexes involves their extracellular domains, membrane-proximal connection …
Structural principles of B cell antigen receptor assembly
Structure determination of the IgM BCR. To determine the cryo-electron microscopy (cryo-EM) structure of a BCR, we engineered the mouse myeloma cell line J558L to stably co-express the mIgM heavy chain and a Flag-tagged Igα–YFP fusion, together with endogenous immunoglobulin λ light chain and Igβ (Fig. 1a and Extended Data Fig. 1a).
B-cell receptor: from resting state to activate - PMC
The BCR is composed of membrane immunoglobulin (mIg); a structure of four (in the case of IgD) or five (IgM) immunoglobulin domains in the heavy chain linked by a hinge, and a short intracellular domain consisting of just three amino acids: lysine, valine, lysine (KVK).
Unveiling the B cell receptor structure | Science - AAAS
2022年8月18日 · The BCR is a multifunctional machine that is responsible for regulating most functions of a B cell. Under the appropriate conditions, antigen binding triggers B cell proliferation and differentiation into antibody-secreting cells. However, this activation requires second signals, without which BCR signaling leads to cell death.
Antigen receptor structure and signaling pathways
The antigen receptors on B cells (the B-cell receptor or BCR) and T cells (the T-cell receptor or TCR) are multiprotein complexes made up of clonally variable antigen-binding chains—the heavy and light immunoglobulin chains in the B-cell receptor, and the TCRα and TCRβ chains in the T-cell receptor—that are associated with invariant ...
RCSB PDB - 7XQ8: Structure of human B-cell antigen receptor of …
2022年5月7日 · The B cell receptor (BCR) initiates immune responses through antigen recognition. We report a 3.3-angstrom cryo-electron microscopy structure of human immunoglobulin M (IgM)-BCR in the resting state. IgM-BCR comprises two heavy chains, two light chains, and the Igα/Igβ heterodimer.