Brain changes in depression - PMC - PubMed Central (PMC)
The present review addresses major depressive disorder (MDD) and the implications of antidepressant treatment in the field of brain neuroplasticity, an effect initially considered adjacent but currently passed as central in the process of remission of MDD.
Brain structure alterations in depression: Psychoradiological …
Numerous studies that focused on gray and white matter have found significant brain region alterations in major depressive disorder patients, such as in the frontal lobe, hippocampus, temporal lobe, thalamus, striatum, and amygdala. The results are inconsistent and controversial because of the different demographic and clinical characteristics.
Where in the Brain Is Depression? - PMC - PubMed Central (PMC)
The nuclei of major neurotransmitters which are thought to be abnormal in depression or the changes in which are produced by antidepressants are found in the brain stem. The raphe nucleus contains the brain serotonergic neurons, the locus coeruleus the norepinephrine neurons and the substantia nigra and ventral tegmentum the dopaminergic neurons.
Comparison of Brain Function and Structure in Patients with Major ...
2024年8月5日 · Through a meta-analysis of brain function and structure in patients with major depression, this study revealed significant differences compared to healthy individuals. These findings provide a basis for further investigation into the …
major depressive disorder, cognition and the brain demonstrate impaired processing speed as it took significantly longer for depressed adults to give a response compared to their healthy peers.
Brain aging in major depressive disorder: results from the
2020年5月18日 · Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD...
Molecular pathways of major depressive disorder converge on
2022年10月6日 · Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous...
Dysregulation of adult hippocampal neuroplasticity in major depression ...
2022年3月30日 · Major depressive disorder (MDD) is one of the commonest psychiatric conditions in the United States and is the leading cause of disability worldwide [1]. Historically, MDD was thought to be a...
Where in the brain is depression? - PubMed
Major depressive disorder is a serious medical illness which is responsible for considerable morbidity and disability. Despite decades of research, the neural basis for depression is still incompletely understood. In this review, evidence from neuroimaging, neuropsychiatric and brain stimulations st …
Toward Circuit Mechanisms of Pathophysiology in Depression
2020年5月1日 · Structural MRI studies indicate that depression is associated with volume reductions in the thalamus, basal ganglia, hippocampus, prefrontal cortex (PFC), and orbitofrontal cortex, and in some studies, in the amygdala and anterior cingulate cortex (14).
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