Cancer Immunotherapy Breakthrough: Dendritic Cell Vaccines
2022年1月24日 · A dendritic cell vaccine is a cross between a vaccine and a cell therapy. These dendritic cells are like immune system factories and make other molecules that activate critical …
Dendritic Cell and Cancer Therapy - PMC - PubMed Central (PMC)
ECF is a mucosal adjuvant, used to formulate mucosal vaccines that can boost the immune response against targeted diseases. Notably, intranasal administration of ECF stimulated the …
Dendritic cells as orchestrators of anticancer immunity and
2024年2月7日 · Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells that regulate adaptive immunity, including against cancer.
Recent Progress in Dendritic Cell-Based Cancer Immunotherapy
Because dendritic cells (DCs) are professional antigen-presenting cells and have the unique ability to link innate and adaptive immunity, they have been regarded as the key target cells for …
Dendritic cells in cancer immunology and immunotherapy
2019年8月29日 · Here the authors describe the roles of dendritic cells in the tumour microenvironment and the different strategies that are being developed to target these cells in …
Dendritic Cells and Their Role in Immunotherapy - PMC
With the advent of immune checkpoint blockade and the ability to identify patient-specific neoantigens, new vaccines, and combinatorial therapies are being evaluated in the clinic. …
Dendritic cell-targeted therapy expands CD8 T cell responses to …
2024年3月13日 · Here the authors generate a model of NSCLC with enhanced mutational load, showing that, while still resistant to ICIs, hypermutated tumors become sensitive to dendritic …
Clinical use of dendritic cells for cancer therapy
2013年11月14日 · We conclude that dendritic cell therapy is a safe and well tolerated immunotherapeutic method that can elicit immunity even in patients with advanced-stage cancer.
Dendritic cell therapy in cancer treatment; the state-of-the-art
2020年8月1日 · In this review article, we first go through the immunobiology of DC, and development of DC vaccines. Then, we concentrate on the DC immunotherapy by highlighting …
Enhancing Dendritic Cell Therapy in Solid Tumors with …
Dendritic cells (DCs) are the most potent antigen-presenting cells and are the key initiator of tumor-specific immune responses. These characteristics are exploited by DC therapy, where …
Clinical Trials Using Therapeutic Autologous Dendritic Cells
Autologous dendritic cells are immune cells generated from patients' own white blood cells that are grown in a special lab and trained to stimulate the immune system to destroy tumor cells. …
Dendritic Cells in Cancer Immunology and Immunotherapy - MDPI
2024年2月28日 · Dendritic cells (DCs) are professional promoters of immune responses against tumor antigens with the outstanding ability to coordinate the innate and adaptive immune …
Engineering dendritic cell vaccines to improve cancer ... - Nature
2019年11月27日 · At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for …
Dendritic cell therapy in cancer treatment; the state-of-the-art
2020年8月1日 · Immunotherapy as an option for cancer treatment has more advantages. Immunotherapy, including cell therapy like Chimeric antigen receptor (CAR)-T cell therapy, …
Research progress on dendritic cell vaccines in cancer …
2022年1月24日 · There are at least two different strategies that use DCs to promote antitumor immunity: in situ vaccination and canonical vaccination. Monocyte-derived DCs (mo-DCs) and …
Can Dendritic Cells Improve ERBB2 Breast Cancer Outcomes?
5 天之前 · Priming the tumor microenvironment with a higher dose of autologous dendritic cells, combined with anti-ERBB2 antibodies, was safe and effective, found a phase 1 study.
Cancer immunotherapy - Wikipedia
Dendritic cell therapy provokes anti-tumor responses by causing dendritic cells to present tumor antigens to lymphocytes, which activates them, priming them to kill other cells that present the …
A dendritic cell cancer vaccine - Nature
2020年9月28日 · Crucial to the development of dendritic cells as vaccines, in the 1990s researchers developed the concept of loading, or ‘pulsing’, dendritic cells ex vivo with tumour …
Dendritic cell-based vaccine prolongs survival and time to next therapy …
2022年2月23日 · To combat cancer by cell-based-therapies, the intrinsic capacity of dendritic cells (DCs) to augment antitumor immune effector cells, such as tumour antigen-specific cytotoxic T …
A dendritic cell vaccine for both vaccination and neoantigen
2024年11月29日 · The generation of neoantigen-specific T cells for adoptive cell therapy (ACT) is challenging. ... by inducing neoantigen-specific immune responses in vivo via dendritic cell …
Dendritic Cells: Crucial Regulators of Immune Responses on Cancer Cells
2024年12月4日 · Dendritic Cells (DCs) play a pivotal role in the immune system, acting as sentinels that capture, process and present antigens to T cells, thus initiating and regulating …
Dendritic Cells and Their Role in Immunotherapy - Frontiers
2020年5月20日 · Understanding how to augment the function of these intratumoral dendritic cells could offer new approaches to enhance immunotherapy, in addition to improving the cytotoxic …
Adjuvant dendritic cell therapy in stage IIIB/C melanoma: the
2024年2月23日 · Autologous natural dendritic cells (nDCs) treatment can induce tumor-specific immune responses and clinical responses in cancer patients.
Dendritic cell-based immunotherapy | Cell Research - Nature
2016年12月27日 · Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor …
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