Regulation of pyruvate metabolism and human disease - PMC
Aberrant pyruvate metabolism plays an especially prominent role in cancer, heart failure, and neurodegeneration. Because most major diseases involve aberrant metabolism, understanding and exploiting pyruvate carbon flux may yield novel treatments that enhance human health.
Pyruvate Metabolism | Pathway - PubChem
2019年5月30日 · When transported into the mitochondrion, pyruvate encounters two principal metabolizing enzymes: pyruvate carboxylase (a gluconeogenic enzyme) and pyruvate dehydrogenase (PDH). With a high cell-energy charge, acetyl-CoA, is able allosterically to activate pyruvate carboxylase, directing pyruvate toward gluconeogenesis.
Regulation of pyruvate metabolism and human disease
2013年12月21日 · Aberrant pyruvate metabolism plays an especially prominent role in cancer, heart failure, and neurodegeneration. Because most major diseases involve aberrant metabolism, understanding and exploiting pyruvate carbon flux may …
An overview of structure, function, and regulation of pyruvate …
In the last step of glycolysis Pyruvate kinase catalyzes the irreversible conversion of ADP and phosphoenolpyruvate to ATP and pyruvic acid, both crucial for cellular metabolism. Thus pyruvate kinase plays a key role in controlling the metabolic flux and ATP production.
Mitochondrial pyruvate transport: a historical perspective and …
Mitochondrial pyruvate metabolism is an important process in normal organ function and pathology. The recent identification of the proteins comprising the MPC opens up vast possibilities for investigation of the roles of altered mitochondrial pyruvate transport in various common acquired diseases.
The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial ... - MDPI
2020年6月18日 · Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation.
Regulation of pyruvate metabolism and human disease
Aberrant pyruvate metabolism plays an especially prominent role in cancer, heart failure, and neurodegeneration. Because most major diseases involve aberrant metabolism, understanding and exploiting pyruvate carbon flux may yield novel treatments that enhance human health.
Regulation of pyruvate metabolism in metabolic-related diseases …
2013年11月12日 · Pyruvate is an obligatory intermediate in the oxidative disposal of glucose and a major precursor for the synthesis of glucose, glycerol, fatty acids, and non-essential amino acids. Stringent control of the fate of pyruvate is critically important for cellular homeostasis.
The Role of Pyruvate Metabolism in Mitochondrial Quality …
2023年5月1日 · Pyruvate metabolism, a key pathway in glycolysis and oxidative phosphorylation, is crucial for energy homeostasis and mitochondrial quality control (MQC), including fusion/fission dynamics and mitophagy.
The Multifaceted Pyruvate Metabolism: Role of the …
2020年7月17日 · Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation.
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