RhoA promotes differentiation of WB-F344 cells into the
2009年2月1日 · When cultured on Matrigel, liver precursor epithelium WB-F344 cells could be induced to differentiate into biliary cells in which RhoA expression was upregulated. To further investigate the role of RhoA in WB cell differentiation initiated by Matrigel treatment, we constructed constitutively active RhoA-expressing vectors and stably transfected ...
RhoA signaling increases mitophagy and protects cardiomyocytes …
2022年6月27日 · We tested the hypothesis that signaling through RhoA, a small GTPase, induces mitophagy via modulation of the PINK1/Parkin pathway as a protective mechanism against ischemic stress.
RhoA as a Key Regulator of Innate and Adaptive Immunity
RhoA acts as a molecular switch that is activated in response to binding of chemokines, cytokines, and growth factors, and via mDia and the ROCK signaling cascade regulates the activation of cytoskeletal proteins, and other factors.
RhoA determines lineage fate of mesenchymal stem cells by
2016年4月29日 · Here we show that TGFβ-activated RhoA/ROCK signalling functions as a molecular switch regarding the fate of MSCs in arterial repair/remodelling after injury. MSCs differentiate into...
Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 ... - Nature
2016年2月25日 · Our results suggest that Rac1, Cdc42 and RhoA regulate different cytoskeletal and adhesion processes to fine tune the highly plastic edge protrusion/retraction dynamics that power cell motility....
Active RhoA Exerts an Inhibitory Effect on the Homeostasis and ...
2022年6月14日 · Here, we report that expression of active and wild‐type RhoA but not dominant‐negative RhoA significantly inhibited endothelial cell proliferation, migration, tube formation, and angiogenic sprouting in vitro.
Optical regulation of endogenous RhoA reveals selection of …
2022年7月12日 · Here, we develop a photoswitchable RhoA guanine nucleotide exchange factor (GEF), psRhoGEF, to precisely control endogenous RhoA activity. Using this optical tool, we discover that peak FA disassembly selectively occurs …
RhoA downregulation in the murine intestinal epithelium results in ...
2024年3月1日 · Rho GTPases are molecular switches regulating multiple cellular processes. To investigate the role of RhoA in normal intestinal physiology, we used a conditional mouse model overexpressing a dominant negative RhoA mutant (RhoA T19N) in the intestinal epithelium.
Activation of RhoA/ROCK regulates NF-κB signaling pathway in ...
2013年4月30日 · In STZ-induced diabetic rats, treatment with ROCK inhibitor fasudil suppressed the RhoA/ROCK activation and NF-κB nuclear translocation, and significantly reduced the renal FN, ICAM-1 and TGF-β1 protein levels. Thus, the RhoA/ROCK pathway may regulate NF-κB to upregulate inflammatory genes and mediate the development of DN.
A current overview of RhoA, RhoB, and RhoC functions in vascular ...
In this review, we aim to provide a current overview of the Rho subfamily as regulators of vascular biology and pathology, analyzing database information and existing literature on expression, protein structure, and interaction with effectors and regulatory proteins.