关于『细胞自噬』，看这一篇就够了！ - 知乎专栏
自噬（autophagy=self-eating）意为自体吞噬，是真核细胞在自噬相关基因（autophagy related gene，Atg）的调控下利用溶酶体降解自身细胞质蛋白和受损细胞器的过程。 自噬可防止细胞损伤，促进细胞在营养缺乏的情况下存活，并对细胞毒性刺激作出反应。 自噬包括生理条件下的基础型自噬和应激条件下的诱导型自噬。 前者是细胞的自我保护机制，有益于细胞的生长发育，保护细胞防止代谢应激和氧化损伤，对维持细胞内稳态以及细胞产物的合成、降解和循环再利用具有重 …
Autophagy and autophagy-related proteins in the immune system
2015年9月18日 · Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic...
Emerging roles of ATG proteins and membrane lipids in ... - Nature
2020年5月26日 · Autophagosome biogenesis is a dynamic membrane event, which is executed by the sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a...
Autophagy genes in biology and disease - Nature
2023年1月12日 · Autophagy (‘self-eating’) is a collection of processes by which cellular components such as proteins and organelles are delivered to the lysosome or vacuole for degradation. Two autophagy...
Autophagy signal transduction by ATG proteins: from hierarchies …
The so-called autophagy-related (ATG) genes and proteins are central to this process. However, several additional molecules contribute to the outcome of an autophagic response. Several review articles describing the molecular process of autophagy have been published in the recent past.
Emerging roles of ATG9/ATG9A in autophagy: implications for cell …
KEYWORDS: ATG proteins, ATG9, ATG9A, autophagy, lipid scramblase, phagophore expansion. Introduction. Macroautophagy/autophagy is a crucial self-degradation mechanism in eukaryotic cells . It is triggered by various stresses, such as starvation, inflammation, and ischemia, and plays a fundamental role in preserving cellular homeostasis
An Overview of Autophagy: Morphology, Mechanism, and Regulation
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The ATG conjugation systems in autophagy - ScienceDirect
2020年4月1日 · Macroautophagy, which is referred to as simply autophagy, is mediated by autophagosomes that engulf a portion of the cytoplasm and fuse with lysosomes. Formation of the autophagosome requires approximately 20 genes (or gene families), which are called core autophagy-related (ATG) genes.
Emerging roles of ATG9/ATG9A in autophagy: implications for cell …
2024年1月7日 · Macroautophagy/autophagy is a crucial self-degradation mechanism in eukaryotic cells [1–3]. It is triggered by various stresses, such as starvation, inflammation, and ischemia, and plays a fundamental role in preserving cellular homeostasis [3–6].
The functions of Atg8-family proteins in autophagy and cancer: …
2020年4月19日 · Autophagy is a multistep degradation process initiated by the formation of a double-membrane compartment called the phagophore, which sequesters cytoplasmic components, soluble proteins, protein aggregates, or even organelles, and ultimately closes to form an autophagosome (Figure 1).