QT Prolonging Drugs - StatPearls - NCBI Bookshelf
2023年7月2日 · Patients using medications that prolong the QT interval should ideally be monitored with an ECG. Some medications induce minimal QT prolongation, and if there is no preexisting QT prolongation, then monitoring is unnecessary. A normal QTc in men is 440 ms or less, and in women, it is 460 ms or less.
Amiodarone: Adverse effects, potential toxicities, and ... - UpToDate
2023年7月24日 · The long half-life of oral amiodarone (25 to 100 days) and the potential severity and irreversible nature of some the adverse effects make early recognition of any potential adverse effects important. As a result, baseline testing and careful monitoring of patients taking amiodarone is essential.
Amiodarone: Guidelines for Use and Monitoring - AAFP
2003年12月1日 · Amiodarone is considered to be a class III drug (Vaughan Williams classification), which indicates that it prolongs the QT interval.
QT prolongation and the antiarrhythmic efficacy of amiodarone:
Amiodarone is an antiarrhythmic agent known to cause prolongation of action potential duration which is reflected in the electrocardiogram as a prolongation of the QT interval.
Drug-Induced QT Prolongation - U.S. Pharmacist
2007年2月20日 · Macrolides, specifically erythromycin, exhibit electrophysiologic effects similar to those of the class III antiarrhythmics (amiodarone, sotalol, ibutilide, and dofetilide). Macrolides can prolong myocardial action potential by dispersing electrical activity over the ventricular wall, leading to a prolonged QT interval or TdP.
QT prolongation and the antiarrhythmic efficacy of amiodarone
Marked prolongation in the QT interval was present in patients who remained alive with amiodarone therapy. A significant difference in percent QT prolongation was seen between the latter patients and those who died suddenly (p less than 0.005).
Medication-Induced QT-Interval Prolongation and Torsades de …
2011年2月18日 · The prolonged depolarization with sodium channels constitutes the major mechanism of QT prolongation. The combination of TCAs and drugs with increased effects on potassium channels may confer a greater risk of TdP and QT prolongation. TCAs noted for their ability to prolong QT include amitriptyline, doxepin, desipramine, and clomipramine. 27
Drug-induced Prolongation of the QT Interval - AAFP
2005年1月1日 · Amiodarone often causes QT prolongation beyond 500 msec, yet rarely causes torsades de pointes. Terfenadine was removed from the market because of associated episodes of torsades de pointes,...
A Case Report on QTc Prolongation: Understanding the …
Amiodarone, a class III antiarrhythmic, is well known for remarkable QTc prolongation. Typically, when hypokalemia is present concomitantly with amiodarone use, it amplifies the risk of torsades de pointes and sudden cardiac death [ 3 ].
Amiodarone-induced QT prolongation in a newly transplanted …
Amiodarone, given to a recipient, might cause QT prolongation in a donor heart after transplantation, possibly due to its long half-life and increased bioavailability caused by interaction with immunosuppressive drugs.