Angiotensin II and the Heart | Hypertension - AHA/ASA Journals
2000年6月1日 · Angiotensin (Ang) II, through the activation of specific Ang II receptors, regulates cardiac contractility, cell communication, and impulse propagation. In addition, Ang II is involved in cardiac remodeling, growth, and apoptosis.
Angiotensin II Stimulation of Cardiac Hypertrophy and Functional ...
2016年3月21日 · Renin–angiotensin system (RAS) plays a pivotal role for salt retention and hypertension, and the sustained RAS activation, by its main effector molecule angiotensin II (Ang II), contributes to the development and progression of heart failure. 12 Besides its hemodynamic effect, Ang II induces cardiac fibrosis, inflammation and aging, 13 and a ...
New Take on the Role of Angiotensin II in Cardiac Hypertrophy …
2011年4月18日 · Increased cardiac Ang II had no impact on heart phenotype under basal conditions but exacerbated ventricular hypertrophy and fibrosis with increased blood pressure. Elevated cardiac Ang II enhanced cardiac myocyte apoptosis, macrophage infiltration, and expression of NADPH oxidase (NOX) 2 and transforming growth factor-β 1 (TGF-β 1 ), whereas ...
Angiotensin II and Angiotensin Receptors 1 and 2—Multifunctional …
Chronic RAS activation in the cardiovascular system increases angiotensin II (Ang II) ratio and plays a major role in the pathogenesis of cardiovascular diseases such as hypertension and heart failure. The RAS consists of the Ang II precursor angiotensinogen; renin; angiotensin-converting enzyme (ACE); Ang II; and Ang II type 1 and type 2 ...
Angiotensin II Signal Transduction: An Update on Mechanisms of ...
The majority of investigation into ANG II signal transduction has focused on ANG II stimulation of the ANG II type 1 and type 2 receptors (AT 1 R, AT 2 R). The AT 1 R is present in various tissues, including vascular smooth muscle, endothelium, heart, brain, kidney, adrenal gland, and adipose tissue and facilitates most of the physiological ...
Angiotensin II cell signaling: physiological and pathological effects ...
Pathologic ANG II-induced signaling in vascular, endothelial, and cardiac cells promotes ROS production, inflammation, platelet activation, altered vasoreactivity, growth, migration, and fibrosis, all of which combine to ultimately cause diseases such as hypertension, atherosclerosis, restenosis, heart failure, chronic kidney disease, insulin ...
Angiotensin II-induced cardiomyocyte hypertrophy in vitro is …
2011年11月10日 · Cardiac hypertrophy occurs as an adaptation to hypertension but a sustained hypertrophic response can ultimately lead to heart failure. Angiotensin-II (Ang II) is released following...
IGF-1 protects against angiotensin II-induced cardiac fibrosis …
2021年7月9日 · Mechanistically, we demonstrated that IGF-1-attenuated AngII-induced cardiac fibrosis through the Akt pathway and through suppression of rho-associated coiled-coil containing kinases...
Cardiac angiotensin II: does it have a function?
2010年11月1日 · angiotensin (ANG) II, in addition to its vasoconstrictor effects, is believed to be a direct mediator of left ventricular hypertrophy and cardiac fibrosis, thus explaining the beneficial cardiac effects of renin-angiotensin system (RAS) blockers in humans.
Angiotensin II Signal Transduction: An Update on Mechanisms of ...
2018年7月1日 · Accumulating evidence reveals the complexity of ANG II signal transduction in pathophysiology of the vasculature, heart, kidney, and brain, as well as several pathophysiological features, including inflammation, metabolic dysfunction, and aging.