ARHGDIA Gene - GeneCards | GDIR1 Protein | GDIR1 Antibody
2024年10月1日 · ARHGDIA (Rho GDP Dissociation Inhibitor Alpha) is a Protein Coding gene. Diseases associated with ARHGDIA include Nephrotic Syndrome, Type 8 and Genetic Steroid-Resistant Nephrotic Syndrome. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases.
ARHGDIA Rho GDP dissociation inhibitor alpha [ (human)]
2024年11月3日 · ARHGDIA mutations (R120X and G173V) from individuals with nephrotic syndrome abrogated interaction with RHO GTPases and increased active GTP-bound RAC1 and CDC42, but not RHOA. Mutations in ARHGDIA need to be considered in the aetiology of heritable forms of nephrotic syndrome.
Activating Transcription Factor 4 (ATF4) modulates Rho …
2016年11月14日 · Here, we find that ATF4 down-regulation in both hippocampal and cortical neuron cultures reduces protein and message levels of RhoGDIα, a stabilizer of the Rho GTPases including Cdc42. This effect...
ARHGDIA mutations cause nephrotic syndrome via defective …
ARHGDIA mutations (R120X and G173V) from individuals with SRNS abrogated interaction with RHO GTPases and increased active GTP-bound RAC1 and CDC42, but not RHOA, indicating that RAC1 and CDC42 are more relevant to the pathogenesis of this SRNS variant than RHOA.
ARHGDIA重组蛋白：细胞形态调控中的作用—艾普蒂生物 - 知乎
2023年11月28日 · ARHGDIA（Rho GDP解离抑制器阿尔法）是一种调节Rho家族GTP酶的蛋白质，对细胞的形态和迁移有重要影响。 ARHGDIA通过抑制Rho蛋白的活性，参与细胞骨架的组织和细胞信号的传递。
Regulation of Rho GTPase crosstalk, degradation and activity by …
2010年4月18日 · RhoGDIs have generally been considered to hold Rho proteins passively in an inactive state within the cytoplasm. Here we describe an evolutionarily conserved mechanism by which RhoGDI1 controls the...
UniProt
2007年1月23日 · Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high ...
Entry - *601925 - RHO GDP-DISSOCIATION INHIBITOR ALPHA; ARHGDIA …
2014年7月23日 · The ARHGDIA gene encodes the Rho-GDP dissociation inhibitor-alpha, which sequesters Rho-GTPases in an inactive state in the cytosol (summary by Gupta et al., 2013). Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors.
Interplay between PCBP2 and miRNA modulates ARHGDIA …
Here, we identified Rho GDP dissociation inhibitor α (ARHGDIA) as a target mRNA that binds to PCBP2, and we uncovered the role of ARHGDIA as a putative metastasis suppressor through analyses of in vitro and in vivo models of EMT and metastasis. Furthermore, we demonstrated that ARHGDIA is a potential target of miR-151-5p and miR-16 in gliomas.
ARHGDIA: a novel gene implicated in nephrotic syndrome
Rho-GTPases are critical regulators of the actin cytoskeleton and when bound to RhoGDIα, they are sequestered in an inactive, cytosolic pool. In the mouse kidney, RhoGDIα was highly expressed in podocytes, a critical cell within the glomerular filtration barrier.
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