Astrocytic endfeet re-cover blood vessels after removal by …
2019年2月4日 · In this study, astrocytic endfeet covering blood vessels were removed by the laser ablation method with two photon laser scanning microscopy in in vivo mouse brain, and the re …
Erratic and blood vessel-guided migration of astrocyte ... - Nature
2022年11月2日 · Here, we show that, by combinational analyses of in vitro and in vivo time-lapse observations and lineage traces, astrocyte progenitors move rapidly and irregularly within the …
Disruption of astrocyte–vascular coupling and the blood–brain …
2014年6月19日 · Astrocytic endfeet cover the entire cerebral vasculature and serve as exchange sites for ions, metabolites and energy substrates from the blood to the brain. They maintain …
Astrocyte Regulation of Blood Flow in the Brain - PMC
The release of vasoactive factors (including arachidonic acid metabolites) from astrocyte endfeet onto blood vessels in the brain plays a key role in regulating cerebral blood flow.
Astrocytes: The Housekeepers and Guardians of the CNS
Astrocytes perform every known housekeeping and homeostatic function in the CNS from structural support and control over molecular homeostasis to regulation of blood flow, …
Astrocyte regulation of blood flow in the brain - PubMed
2015年3月27日 · Tonic release of both 20-HETE and ATP from astrocytes constricts vascular smooth muscle cells, generating vessel tone. Under pathological conditions, including …
Regulation of blood-brain barrier integrity by Dmp1 -expressing
2024年6月28日 · Here, we investigate the role of a specific subset of astrocytes in the regulation of BBB integrity. We showed that Dmp1- expressing astrocytes transfer mitochondria to …
Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy ...
We show that astrocytic Slc4a4 is required for normal astrocyte morphological complexity and BBB function. Multi-omics analyses identified increased astrocytic secretion of CCL2 coupled …
APOE4 derived from astrocytes leads to blood–brain barrier …
2021年12月27日 · We found that humanized APOE4, but not APOE2 or APOE3, mice show a leaky blood–brain barrier, increased MMP9, impaired tight junctions, and reduced astrocyte …
Astrocyte endfoot formation controls the termination of …
2023年1月18日 · Astrocyte-derived semaphorins 3a and 6a act to repel OPCs from blood vessels at the cessation of their perivascular migration and, in so doing, permit subsequent OPC …
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