Monocytes in atherosclerosis: subsets and functions - PMC
Blood monocytes in atherosclerosis. a | Atherogenesis and the formation of fatty streaks. Monocytes are recruited (influx) into the intima and may differentiate into macrophages that accumulate lipids and cholesterol derivatives, form foam cells in …
The March of Monocytes in Atherosclerosis | Circulation Research
2020年5月7日 · Monocyte and macrophage subsets contribute to the initiation, progression, and thrombus formation stages of atherosclerosis. A, Bone marrow–derived monocytes in circulation are classified as conventional monocytes (cMos) and patrolling monocytes (pMos). During atherogenesis, the Ly6C+ cMos subpopulation infiltrates the intima, whereas the ...
Monocyte Fate in Atherosclerosis | Arteriosclerosis, Thrombosis, …
2014年12月23日 · Monocytes and their descendant macrophages are essential to the development and exacerbation of atherosclerosis, a lipid-driven inflammatory disease. Lipid-laden macrophages, known as foam cells, reside in early lesions and advanced atheromata.
The Entry and Egress of Monocytes in Atherosclerosis: A …
In accordance with “the response to injury” theory, the entry of monocytes into the intima guided by inflammation signals, taking up cholesterol and transforming into foam cells, and egress from plaques determines the progression of atherosclerosis. ...
Monocyte Recruitment, Specification, and Function in Atherosclerosis
Blocking approaches directed against CD11b, ICAM1, LFA-1, or VLA-4 have all shown dramatic defects in monocyte recruitment in models of atherosclerosis. Once monocytes access the peripheral tissues, they differentiate to macrophage populations and require CSF-1 for their survival and maintenance [51,52].
Monocytes in Coronary Artery Disease and Atherosclerosis:
In this review we discuss the functional role of monocytes and their different subpopulations in atherosclerosis, acute coronary syndromes, cardiac healing, and recovery with an aim of critical evaluation of potential future therapeutic targets in atherosclerosis and its complications.
Monocyte-Macrophages and T Cells in Atherosclerosis
2017年10月10日 · The major subpopulation of monocytes that contribute to atherosclerosis progress are Ly6c hi monocytes, which enter lesions in response to subendothelially retained apoB-lipoproteins (LP) and subsequent chemokine release by activated endothelial cells. After differentiation into macrophages, they undergo a variety of phenotypic changes under ...
Monocytes in atherosclerosis: subsets and functions - PubMed
Chronic inflammation drives atherosclerosis, the leading cause of cardiovascular disease. Over the past two decades, data have emerged showing that immune cells are involved in the pathogenesis of atherosclerotic plaques. The accumulation and continued recruitment of leukocytes are associated with t …
The fate of monocytes in atherosclerosis - PMC - National …
If CD16 + human monocytes promote atherosclerosis, it remains unclear whether they do so by migrating into the plaque environment or by carrying out a role elsewhere. In mice, the two subsets are both recruited to atherosclerotic plaques, but CCR2 hi Ly-6C hi monocytes, counterparts to the major subset in humans, are more robustly recruited to ...
Monocytes in Coronary Artery Disease and Atherosclerosis
2013年10月22日 · Monocytes, as representatives of the innate immune system, play a major role in the initiation, propagation, and progression of atherosclerosis from a stable to an unstable state. Experimental data support a role of monocytes in acute coronary syndromes and in outcome post-infarction; however, limited research has been done in humans.