Is There a Role of Autophagy in Depression and Antidepressant ... - PubMed
2019年5月15日 · This minireview highlights the emerging evidence for the involvement of autophagy in the pathology and treatment of depression and discusses current limitations as well as potential avenues for future research.
The interaction between autophagy and neuroinflammation in …
2021年6月1日 · Antidepressant mechanism of autophagy in inflammation-related depression. Inflammasome mediated inflammatory pathways associated with depression. By sensing stress signals, NLRP3 interacts with the adaptor protein ASC, which further recruits pro-caspase-1 to form the NLRP3 inflammasome.
Frontiers | Is There a Role of Autophagy in Depression and ...
2019年5月14日 · Autophagy has been linked to several diseases, more recently also including stress-related diseases such as depression. A growing number of publications report on the role of autophagy in neurons, also referred to as “neuronal autophagy” on the one hand, and several studies describe effects of antidepressants—or of compounds that exert ...
Autophagy: A New Mechanism for Esketamine as a Depression …
2022年8月21日 · ESK acts as an antidepressant by attenuating autophagy; essentially, ESK reverses the LPS effects on autophagy impairment via regulating mTOR-BDNF signaling. Our results suggest that treatment with ESK is a beneficial therapeutic strategy to treat depression in addition to autophagy impairment and neuroinflammation.
Antidepressants act by inducing autophagy controlled by
2018年7月23日 · We found that widely used antidepressants such as amitriptyline and fluoxetine induce autophagy in hippocampal neurons via the slow accumulation of sphingomyelin in lysosomes and Golgi membranes...
Is Autophagy Involved in the Diverse Effects of Antidepressants?
2019年1月12日 · Recently, autophagy has also been linked to depression, mainly through its involvement in the action of antidepressants. Some antidepressant drugs and psychotropic medication have been reported to exert beneficial effects in other diseases, for example, in cancer and neurodegenerative diseases.
Molecular network of neuronal autophagy in the pathophysiology …
2015年8月8日 · Here, we discuss whether the dysregulation of autophagy contributes to the pathophysiology and treatment of MDD and summarize the current evidence that shows the involvement of autophagy in MDD. Major depressive disorder (MDD) is a complicated multifactorial induced disease, characterized by depressed mood, anhedonia, fatigue, and …
Molecular network of neuronal autophagy in the pathophysiology …
2015年8月8日 · Recently, many studies have shown that antidepressants regulate autophagy. In fact, autophagy, a conserved lysosomal degradation pathway, is essential for the central nervous system. Dysregulation of autophagic pathways, such as the mammalian target of rapamycin (mTOR) signaling pathway and the beclin pathway, has been studied in ...
Stress-primed secretory autophagy promotes extracellular BDNF ...
2021年7月30日 · Secretory autophagy is a recently described pathway in which autophagosomes fuse with the plasma membrane rather than with lysosomes. Here, we demonstrate that glucocorticoid-mediated...
Targeting autophagy to counteract neuroinflammation: A novel ...
2024年4月1日 · Studies have shown that the expression of autophagic markers in the brain and peripheral inflammatory mediators are dysregulated in depression. Autophagy-related genes regulate the level of autophagy and change the inflammatory response in depression. Depression is related to several aspects of immunity.
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