The axolotl - Nature Methods
2023年8月8日 · In this image, skeleton (magenta) and muscle (cyan) can be observed in a regenerating limb.
The specialist in regeneration—the Axolotl—a suitable ... - Nature
2022年6月30日 · Axolotl is able to regenerate large parts of the lost appendages, including a complete patterned skeleton. In the past years, limb regeneration was studied in detail, and the cellular and...
The axolotl limb: A model for bone development, regeneration …
2007年1月1日 · In this study, we report the cloning and characterization of two axolotl genes; Cbfa-1, a transcription factor that controls the remodeling of cartilage into bone and PTHrP, known for its involvement in the differentiation and maturation of chondrocytes.
Axolotl: A resourceful vertebrate model for regeneration and …
2022年7月30日 · Vertebrate regeneration models, such as Ambystoma mexicanum (Axolotl), share many functional and structural proteins and signal pathways with mammalians; therefore, conveying the message generated i...
Multi-species atlas resolves an axolotl limb development and ...
2023年10月10日 · Here, by leveraging a single-cell transcriptomics-based multi-species atlas, composed of axolotl, human, mouse, chicken, and frog cells, we first establish that axolotls contain cells with AER...
Live Imaging of Axolotl Digit Regeneration Reveals Spatiotemporal ...
Connective tissues—skeleton, dermis, pericytes, fascia—are a key cell source for regenerating the patterned skeleton during axolotl appendage regeneration. This complexity has made it difficult to identify the cells that regenerate skeletal tissue.
The axolotl limb: A model for bone development, regeneration …
2007年1月1日 · Among vertebrates, urodele amphibians (e.g., axolotls) have the unique ability to perfectly regenerate complex body parts after amputation. The limb has been the most widely studied due to the presence of three defined axes and its ease of manipulation.
Osteoclast-mediated resorption primes the skeleton for ... - eLife
2022年10月11日 · In vivo evaluation of mineralized skeleton in the regenerating axolotl limb reveals a significant osteoclast-driven resorption as an early event with long-lasting impact for tissue integration.
Understanding The Fascinating Body Structure Of Axolotls
2024年5月26日 · Underneath its skin, the axolotl has a complex skeletal structure that provides support and protection for its vital organs. Its backbone runs the length of its body, connecting to its unique rib cage structure.
Single-cell analysis uncovers convergence of cell identities during ...
2018年9月27日 · Unlike most vertebrate limbs, the axolotl limb regenerates the skeleton after amputation. Dermal and interstitial fibroblasts have been thought to provide sources for skeletal regeneration, but it has been unclear whether preexisting stem cells or dedifferentiation of fibroblasts formed the blastema.