Amyloid beta - Wikipedia
Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...
Amyloid Beta Peptide - StatPearls - NCBI Bookshelf
2023年8月28日 · Amyloid beta peptide is a 42-amino acid peptide and derives from the precursor protein, amyloid beta precursor protein (APP). The amyloid beta precursor protein is a transmembrane glycoprotein that spans the membrane once.
Amyloid beta: structure, biology and structure-based …
2017年7月17日 · Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases.
The Amyloid-β Pathway in Alzheimer’s Disease - Nature
2021年8月30日 · We discuss the evidence highlighting a differentiated interaction of distinct Aβ species with other AD-related biological mechanisms, such as tau-mediated, neuroimmune and inflammatory changes,...
Amyloid Beta in Aging and Alzheimer’s Disease - PMC
Aβ is a peptide derived from amyloid precursor protein (APP) by proteolytic cleavage of beta and gamma secretases. APP is a glycoprotein that plays a significant role in maintaining neuronal homeostasis like signaling, neuronal development, and intracellular transport.
Alzheimer’s Disease and the β-Amyloid Peptide - PMC
Familial early onset forms of AD are associated with mutations either in the precursor protein for Aβ (the β-amyloid precursor protein, APP) or in presenilin-1 (PS1) or presenilin-2 (PS2). Either PS1 or PS2 can be the catalytic subunit of γ-secretase, which is the final endoprotease in the pathway that generates the peptide.
Amyloid beta: structure, biology and structure-based therapeutic ...
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. Aβ accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer's disease, which is the most common form …
β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s …
2015年9月30日 · Aβ is generated from amyloid precursor protein through sequential cleavage of β- and γ-secretases while Aβ removal is dependent on the proteolysis and lysosome degradation system. Here, we overviewed the biogenesis and toxicity of Aβ as well as the regulation of Aβ production and clearance.
The Development of Amyloid β Protein Deposits in the Aged …
2006年3月8日 · Accumulation of Aβ takes place in senile plaques and in cerebrovascular deposits as a result of an imbalance between Aβ production and clearance. This Review describes the different types of Aβ deposits, which can be distinguished by their morphology and by the hierarchical involvement of distinct areas of the brain in Aβ deposition.
Amyloid Beta Protein - an overview | ScienceDirect Topics
Amyloid Beta Protein refers to a large transmembrane protein that is cleaved by enzymes to produce various peptides, including Aβ40 and Aβ42. Aβ42 is the dominant form and tends to accumulate in amyloid plaques, leading to neurotoxicity.