Tolerance and resistance of microbial biofilms - Nature
2022年2月3日 · In this Review, we present the extent of the clinical problem, and the mechanisms underlying the tolerance of biofilms to antibiotics and to host responses. We also explore the role of biofilms...
Mechanisms of antimicrobial resistance in biofilms
2024年10月1日 · The unique properties of cells in a biofilm promotes infection and underpins antibiotic resistance. Biofilm formation is an intricate process that involves the production of extracellular...
Biofilms as Promoters of Bacterial Antibiotic Resistance and …
Biofilms are associations of microorganisms embedded a self-produced extracellular matrix. They create particular environments that confer bacterial tolerance and resistance to antibiotics by different mechanisms that depend upon factors such as biofilm composition, architecture, the stage of biofilm development, and growth conditions.
Understanding the Mechanism of Bacterial Biofilms Resistance to ...
Bacterial biofilm has increased antibiotic resistance and involved in many persistent diseases. Inside biofilm, several mechanisms confer the multi-factorial resistance to antibiotics. In this review, we are highlighting the molecular mechanism of biofilm and the role of the matrix for antimicrobial resistance.
Understanding the Mechanism of Bacterial Biofilms Resistance to ...
The increased antibiotic resistance of biofilm is due to (i) limited diffusion of antimicrobial agents through the biofilm matrix, (ii) communication of the antimicrobial agents with the biofilm matrix (polymer and cells), (iii) enzyme-mediated resistance, (iv) levels of metabolic activity inside the biofilm, (v) genetic adaptation, (vi) efflux ...
Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance ...
5 天之前 · Biofilms, composed of structured communities of bacteria embedded in a self-produced extracellular matrix, pose a significant challenge due to their heightened resistance to antibiotics and immune responses. This review highlights the mechanisms underpinning antibiotic resistance within bacterial biofilms, elucidating the adaptive strategies employed by microorganisms to withstand conventional ...
Approaches for Mitigating Microbial Biofilm-Related Drug Resistance…
2021年3月26日 · Biofilm-related resistance are dependent on several factors including cell density, QS, ECMs, overexpression of drug targets, up-regulation of drug efflux pumps, persister cells, and antimicrobial tolerance.
The Association between Biofilm Formation and Antimicrobial Resistance …
Biofilm-producing bacteria show a remarkable drug resistance capability, leading to an increase in morbidity and mortality. This results in enormous economic pressure on the healthcare sector. The development of biofilms is a complex phenomenon governed by multiple factors.
Biofilms: Understanding the structure and contribution towards ...
2023年6月1日 · Bacterial biofilms play a crucial role in acquiring antibiotic resistance. Prophylactic or therapeutic strategies can combat bacterial biofilm-associated infections. The biofilm is a bacterial colony wrapped in an auto-produced polymer matrix …
Relationship of Biofilm Formation with Antibiotic Resistance, …
1 天前 · Multi-drug resistant (MDR) Acinetobacter baumannii causes nosocomial infections due to a plethora of virulence determinants like biofilm formation which are pivotal to its survival and pathogenicity. Hence, investigation of these mechanisms in currently circulating strains is required for effective infection control and drug development.
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