A view on drug resistance in cancer - Nature
2019年11月13日 · We propose four general solutions to drug resistance that are based on earlier detection of tumours permitting cancer interception; adaptive monitoring during therapy; the addition of novel drugs...
Drug Resistance in Cancer: An Overview - PMC - PubMed Central …
The repair of damaged DNA has a clear role in anticancer drug resistance. In response to chemotherapy drugs that either directly or indirectly damage DNA, DNA damage response (DDR) mechanisms can reverse the drug-induced damage.
Cancer chemotherapy resistance: Mechanisms and recent
2023年8月24日 · The most significant drawbacks of systemic chemotherapy are rapid clearance from the circulation, the drug's low concentration in the tumor site, and considerable adverse effects outside the tumor. Several ways have been developed to boost neoplasm treatment efficacy and overcome medication resistance.
Why Do Cancer Treatments Stop Working? - NCI
When cancer cells resist the effects of drugs used for treatment, they can grow and reform tumors, a process known as recurrence or relapse. Sometimes resistance develops quickly, within a matter of weeks of starting treatment. In other cases, it develops months, or even years, later.
Resistance to cancer chemotherapy: failure in drug response …
2015年7月15日 · Chemotherapy resistance can arise due to several host or tumor-related factors. However, most current research is focused on tumor-specific factors and specifically genes that handle expression of pumps that efflux accumulated …
Understanding and targeting resistance mechanisms in cancer
2023年5月24日 · Drug resistance in cancer can arise from genetic, epigenetic, and microenvironmental factors. A better understanding of the molecular mechanisms underlying cancer resistance is necessary to develop effective strategies to overcome it.
From resistance to resilience: Uncovering chemotherapeutic resistance …
2023年11月1日 · This review aims to open a new avenue for researchers to lower the resistance to the existing chemotherapeutic agents, develop new therapeutic agents with low resistance potential, and establish possible prognostic markers for chemotherapy resistance.
Molecular mechanisms of chemo‐ and radiotherapy resistance …
Cancer cells can develop resistance to chemotherapy through a variety of mechanisms; for example, they can attenuate the accumulation of anticancer drugs, activate detoxification systems, enhance DNA damage repair, and evade drug‐induced cell death. 172 The phenomenon of MDR during chemotherapy is the main reason for the limited clinical ...
Unveiling the mechanisms and challenges of cancer drug resistance
2024年2月12日 · Chemotherapeutic drugs are effective on cancer cells as they enter into the cells and activate various anti-cancer pathways, leading to DNA damage and cell death. In resistant cells, cancer cells modulate drugs or produce a barrier to them which collectively resulted in decreasing their effectivity on cancer cells.
Insights into molecular mechanisms of chemotherapy resistance …
2024年4月1日 · Chemotherapy induces diverse gene and protein changes, reshaping metabolic processes significantly. This review identifies shared drug resistance mechanisms, suggesting targets for combined therapies in diverse cancers.
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