A Genetic Predictive Model for Canine Hip Dysplasia: Integration …
2015年4月13日 · The CHST3 gene encodes a sulfotransferase involved in chondroitin sulfate (CS) biosynthesis. CS is a structural component of the joint cartilage essential for its biomechanical properties, and so CHST3 an interesting and promising candidate gene for CHD.
(PDF) A Genetic Predictive Model for Canine Hip ... - ResearchGate
2015年4月13日 · The aim of this study was polymorphisms in the exon 2 and 3ʹ UTR regions of the CX3CR1 gene were determined and their effects on the development of Canine Hip Dysplasia (CHD) in three dog...
The markers of the predictive DNA test for canine hip dysplasia …
2024年9月30日 · This study revealed, for the first time, a regulatory mechanism involving methylation of the CHST3 gene concerning orthopedic disorders in dogs. Furthermore, these findings clearly establish CHST3 as a significant candidate gene for CED.
Study on canine hip dysplasia and its diagnosis by imaging and ...
2021年5月19日 · Gene set enrichment analysis revealed that genes involved in extracellular matrix structure, epithelial to mesenchymal transition, myogenesis, growth factor signaling, cancer and immune...
An across-breed validation study of 46 genetic markers in canine …
2021年1月21日 · We execute a validation study of 46 genetic markers in a cohort of nearly 1600 dogs from ten different breeds. We categorize the dogs into cases and controls according to the hip scoring system defined by the Fédération Cynologique Internationale (FCI). We validate 21 different loci associated on fourteen chromosomes.
The markers of the predictive DNA test for canine hip dysplasia …
2024年9月10日 · Our findings revealed a remarkable relationship between SNP2 genotypes and methylation patterns, shedding light on the underlying mechanism that partially explains the genotype-phenotype correlation in canine CHST3. These groundbreaking findings offer essential insights for future, more extensive investigations into canine orthopedic health.
The association of genetic polymorphisms of bone formation genes …
In a study aiming to develop a genetic predictive model based on seven SNPs, researchers found two strongly CHD associated SNPs. One of them is 14 bp upstream and the other one is 1051 bp upstream carbohydrate chondroitin 6 sulfotransferase gene (CHST3), which affects chondroitin sulfate biosynthesis (Bartolome et al., 2015 ).
The markers of the predictive DNA test for canine hip dysplasia …
Three specific SNPs previously associated with the risk of canine hip dysplasia demonstrated a potentially stronger correlation with elbow dysplasia. Notably, the SNP at nucleotide position 22691322, located near the canine CHST3 gene, displayed significance as a marker in multivariable logistic regression analysis.
A Genetic Predictive Model for Canine Hip Dysplasia: Integration …
Canine hip dysplasia is one of the most prevalent developmental orthopedic diseases in dogs worldwide. Unfortunately, the success of eradication programs against this disease based on radiographic diagnosis is low.
Emerging insights into the genetic basis of canine hip dysplasia
Canine hip dysplasia (CHD) is the most common inherited polygenic orthopedic trait in dogs with the phenotype influenced also by environmental factors. This trait was described in the dog in 1935 and leads to a debilitating secondary hip ...
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