The resistance mechanisms of bacteria against ciprofloxacin and …
The increasing incidence of ciprofloxacin-resistant pathogens jeopardizes the continued empiric use of ciprofloxacin and raises the urgent need to develop novel ciprofloxacin derivatives potent against both drug-susceptible and drug-resistant pathogens and discover useful synergism between ciprofloxacin and other antibacterial agents.
Prediction of ciprofloxacin resistance in hospitalized patients …
2023年3月28日 · Due to the frequent use of ciprofloxacin, bacteria have developed high rates of resistance to it, which means they continue to grow, reducing the effectiveness of treatment. The aim of this...
CIPROFLOXACIN RESISTANCE PATTERN AMONG BACTERIA ISOLATED …
2016年7月11日 · Antimicrobial resistance has been observed mainly for ampicillin, sulfamethoxazole + trimethoprim and ciprofloxacin. Moreover, E. coli has shown the highest rate of ciprofloxacin resistance, reaching 36% of ciprofloxacin resistant strains in 2014.
Multiple mechanisms contributing to ciprofloxacin resistance …
2018年8月16日 · To elucidate mechanisms underlying ciprofloxacin (CIP) resistance in Gram-negative pathogens causing infections to cancer patients, 169 isolates were investigated. Broth microdilution assays...
A role for the stringent response in ciprofloxacin resistance in
2024年4月13日 · Here we report that when P. aeruginosa is plated on ciprofloxacin (cipro) plates, the majority of cipro-resistant (ciproR) colonies observed at and after 48 h of incubation carry mutations...
Ciprofloxacin resistance in community- and hospital-acquired
2015年11月25日 · Compared to the community setting, resistance to ciprofloxacin was significantly higher in the hospital setting (pooled resistance 0.38, 95 % CI 0.36-0.41 versus 0.27, 95 % CI 0.24-0.31 in community-acquired UTIs, P < 0.001). Resistance significantly varied by region and country with the highest resistance observed in developing countries.
The resistance mechanisms of bacteria against ciprofloxacin and …
2022年12月21日 · Despite the outstanding qualities of this antibiotic, Salmonella typhi, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa have all shown an increase in ciprofloxacin resistance over time. The rise of infections that are resistant to ciprofloxacin shows that new pharmacological synergisms and derivatives are required.
Gene-Gene Interactions Dictate Ciprofloxacin Resistance in
2021年6月17日 · We used this information to predict ciprofloxacin resistance/susceptibility for 274 isolates of P. aeruginosa from their genome sequences. Antibiotic susceptibility profiles were predicted correctly for 84% of the isolates.
Prevalence and mechanisms of ciprofloxacin resistance in
2023年7月17日 · In total, 28.03% of E. coli isolates were phenotypically resistant to ciprofloxacin. Based on sources of isolation, 64.63%, 51.51%, 33.33%, 14.70%, 10.22% and 8.33% of isolates from clinical specimens, hospital wastewater, livestock wastewater, municipal wastewater, healthy children and poultry wastewater were ciprofloxacin-resistant, respectively.
Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance ...
2021年6月22日 · Resistance to the broad-spectrum antibiotic ciprofloxacin is detected at high rates for a wide range of bacterial pathogens. To investigate the dynamics of ciprofloxacin resistance development, we applied a comparative resistomics workflow for three clinically relevant species of Gram-negative bacteria: Escherichia coli , Acinetobacter ...