Copper tolerance in bacteria requires the activation of multiple ...
2020年4月23日 · In this review, we describe the mechanisms of copper toxicity in bacteria and the bespoke adaptation pathways that assuage it. We show that copper excess generates distinctive pleiotropic effects in the cell, and that different stress responses complement the copper homeostasis system in defending the cell against copper toxicity.
Metallic Copper as an Antimicrobial Surface - PMC
Bacteria evolved a range of mechanisms to protect themselves from the toxic effects of copper ions: extracellular sequestration of copper ions, relative impermeability of the outer and inner bacterial membranes to copper ions, metallothionein-like copper-scavenging proteins in the cytoplasm and periplasm, and active extrusion of copper from the ...
Copper tolerance and virulence in bacteria - PMC
The principle mechanisms of copper tolerance in bacteria include: 1) Transmembrane copper export, occurring from the cytoplasm into the periplasmic space or into the extracellular milieu; 2) Copper sequestration by metallothioneins; and 3) Oxidation of Cu(I) by multi-copper oxidases to generate the less toxic Cu(II) ion.
Contact killing and antimicrobial properties of copper
2017年12月27日 · Gram-negative bacteria activate copper-ATPase export and chaperone gene transcription via an ‘activator-type’ (CueR-like and CusRS-like) when cytoplasmic and periplasmic concentrations of copper increase. The CueR-like are one-component regulators that respond to cytoplasmic copper concentration while the CusRS-like are two-component ...
Copper tolerance and virulence in bacteria - PubMed
These discoveries suggest bacterial copper intoxication is a component of host nutritional immunity, thus expanding our knowledge of the roles of copper in biology. This review summarizes our current understanding of copper tolerance in bacteria, and the extent to which these pathways contribute to bacterial virulence within the host.
Copper tolerance in bacteria requires the activation of multiple ...
Copper is a required micronutrient for bacteria and an essential cofactor for redox-active cuproenzymes. Yet, excess copper is extremely toxic, and is exploited as a bacteriocide in medical and biotechnological applications and also by the mammalian immune system.
Metal homeostasis and resistance in bacteria - Nature
2017年3月27日 · In this Review, we focus on the processes that enable bacteria to maintain metal homeostasis, in particular, of the three most important metals for metabolism — zinc, iron and manganese.
Copper Disposition in Bacteria - ScienceDirect
2019年1月1日 · In bacteria, copper homeostasis minimally requires three proteins: a chaperone, a pump, and a regulator of transcription. The chaperone binds excess cytoplasmic copper and donates it to the regulator to induce the copper homeostatic genes, and to the pump for export.
Copper tolerance and virulence in bacteria - Oxford Academic
2015年1月23日 · These discoveries suggest bacterial copper intoxication is a component of host nutritional immunity, thus expanding our knowledge of the roles of copper in biology. This review summarizes our current understanding of copper tolerance in bacteria, and the extent to which these pathways contribute to bacterial virulence within the host.
Copper toxicity and the origin of bacterial resistance--new insights ...
In oxic conditions, copper can catalyze a Fenton-like reaction that may cause lipid peroxidation and protein damage. The inherent ability of copper to inflict damage upon multiple cellular functions has been harnessed by macrophages and perhaps amoeba to kill and later digest bacteria and other microorganisms.