- DNA helicases are essential during DNA replication because they separate double-stranded DNA into single strands allowing each strand to be copied.www.nature.com/scitable/definition/helicase-307/
Special Issue: DNA Helicases: Mechanisms, Biological Pathways, …
This Genes Special Issue provides diverse and informative perspectives on a spectrum of DNA helicase proteins and teaches lessons about their molecular and genetic functions and, more broadly, their roles in genome homeostasis.
仅显示来自 pmc.ncbi.nlm.nih.gov 的搜索结果Loading and activation of DNA replicative helicases: the key step …
In this review, we focus on the initiation step of DNA replication, especially loading of replicat…
History of DNA Helicases - PMC - PubMed Central (PMC)
Bulk biochemical measurements of DNA helicase activity have been highly informative for ch…
DNA Helicases: Structure, Types, Functions, Examples - Microbe …
- Two different types of helicases structure exist, those rings forming hexameric structures and those that do not.
- A ring structure has a central channel that encircles the nucleic acid. The stability and processivity of the enzyme increase with increasing topological links between the protein and the nucleic a...
- Two different types of helicases structure exist, those rings forming hexameric structures and those that do not.
- A ring structure has a central channel that encircles the nucleic acid. The stability and processivity of the enzyme increase with increasing topological links between the protein and the nucleic a...
- All hexameric helicases are homohexamers except the eukaryotic minichrosomal maintenance helicases.
- Helicase motifs mean nine short conserved amino acid sequence finger-prints (designated Q, I, la, lb, II, III, IV, V, and VI) contained in most of the helicases from different organisms.
Helicase - Wikipedia
Helicases are a class of enzymes thought to be vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor proteins that move directionally along a nucleic acid phosphodiester backbone, separating two hybridized nucleic acid strands (hence helic- + -ase), using energy from ATP hydrolysis. There are many helicases, representing the great variety …
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The mechanism of DNA unwinding by the eukaryotic replicative …
2019年5月14日 · The eukaryotic replicative helicase unwinds DNA by executing a biased random walk with frequent entrance into one of three long lifetime pauses.
The ring-shaped hexameric helicases that function at …
2018年1月29日 · DNA replication requires separation of genomic duplex DNA strands, an operation that is performed by a hexameric ring-shaped helicase in all domains of life.
Loading and activation of DNA replicative helicases: the key step …
In this review, we focus on the initiation step of DNA replication, especially loading of replicative DNA helicase onto origins and discuss its diversity as well as general features in various …
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Unwinding of a DNA replication fork by a hexameric viral helicase
2021年9月20日 · Here we present the cryo-EM structure of the full-length E1 helicase from papillomavirus, revealing all arms of a bound DNA replication fork and their interactions with …
Special Issue: DNA Helicases: Mechanisms, Biological Pathways, …
2021年3月1日 · DNA helicases have emerged as a prominent class of nucleic acid-metabolizing enzymes that play important roles in genome maintenance and cellular homeostasis [...].
DNA Helicases: New Breeds of Translocating Motors …
1996年7月26日 · DNA helicases play essential roles in key biological processes such as the replication, repair, recombination, and transcription of DNA.
History of DNA Helicases - PMC - PubMed Central (PMC)
Bulk biochemical measurements of DNA helicase activity have been highly informative for characterizing substrate specificity, modulation of catalytic activity by protein interactions and …
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