Complex wireframe DNA nanostructures from simple building …
2019年3月6日 · Here, revisiting the original wireframe framework entirely made of short synthetic strands, we demonstrate a design paradigm that circumvents the sophisticated routing and size limitations ...
Designer nanoscale DNA assemblies programmed from the top …
2016年5月26日 · We apply asymmetric polymerase chain reaction (aPCR) to generate custom ssDNA scaffolds that result in high-fidelity folding of DNA nanoparticles of diverse shapes and sizes, which are also verified to fold in low salt concentrations due their open wireframe design.
DNA wire-frame objects. (A) DNA cube [18], (B) truncated octahedron …
The field of structural DNA nanotechnology has evolved remarkably—from the creation of artificial immobile junctions to the recent DNA–protein hybrid nanoscale shapes—in a span of about 35 ...
Increasing Complexity in Wireframe DNA Nanostructures
2020年4月16日 · In this focused review, we discuss the recent development of wireframe DNA nanostructures—methods relying on meshing and rendering DNA—that may overcome these obstacles. In addition, we describe each available technique and …
Rapid prototyping of arbitrary 2D and 3D wireframe DNA …
2021年9月11日 · We tested the ability of ATHENA to generate high-quality wireframe DNA origami structures, which also allows users to further functionalize such structures with other materials conveniently.
Cascaded Enzyme Reactions over a Three-Dimensional, Wireframe DNA …
2022年2月2日 · This library covers various cascade architectures for the DNA octahedron topology, namely relating to combinations of external–internal (Group EI) and internal–internal (Group II) enzyme arrangements where 3D layouts may affect the reaction.
Automated Sequence Design of 3D Polyhedral Wireframe DNA …
3D polyhedral wireframe DNA nanoparticles (DNA-NPs) fabricated using scaffolded DNA origami offer complete and independent control over NP size, structure, and asymmetric functionalization on the 10–100 nm scale. ... Four-way and five-way junction objects were additionally evaluated using a regular octahedron of 84-bp edge length and a ...
Cascaded Enzyme Reactions over a Three-Dimensional, Wireframe DNA …
2022年1月7日 · As the ability to define nanoscale structure has grown, it is critical to fully deconstruct the impact of enzyme organization at the single-scaffold level. Here, we present an open, three-dimensional (3D) DNA wireframe octahedron which is used to create a library of spatially arranged organizations of glucose oxidase and horseradish peroxidase.
Complex wireframe DNA origami nanostructures with multi-arm junction ...
2015年7月20日 · Here, we report a design strategy for fabricating finite-size wireframe DNA nanostructures with high complexity and programmability.
Hierarchical Fabrication of DNA Wireframe Nanoarchitectures …
2020年12月2日 · To achieve satisfying therapeutic efficiency, it is essential to develop innovative targeting systems for precise and efficient delivery of anticancer drugs. In this work, a hierarchical self-assembly strategy was applied to fabricate a core–shell nanoarchitecture composed of a DNA octahedral wireframe and chemodrug-functionalized Sgc8c aptamer.