Dendritic Cell and Cancer Therapy - PMC - PubMed Central (PMC)
Dendritic cells (DCs) are acknowledged as the most potent professional antigen-presenting cells (APCs), able to induce adaptive immunity and support the innate immune response. In this regard, DCs represent a promising means for cancer vaccines to strengthen the anti-cancer immune response to overcome the immunosuppressive tumor microenvironment.
Dendritic cells as orchestrators of anticancer immunity and ...
2024年2月7日 · Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells that regulate adaptive immunity, including against cancer. Therefore, understanding the precise...
Trial watch: Dendritic cell (DC)-based immunotherapy for cancer
Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable development over recent decades. However, this field is currently in a state of flux toward niche-applications, owing to recent paradigm-shifts in immuno-oncology mobilized by T cell-targeting immunotherapies.
Dendritic Cells and Their Role in Immunotherapy - PMC
Understanding how to augment the function of these intratumoral dendritic cells could offer new approaches to enhance immunotherapy, in addition to improving the cytotoxic and targeted therapies that are partially dependent upon a robust immune response for their efficacy.
Dendritic cells in cancer immunology and immunotherapy - Nature
2019年8月29日 · Dendritic cells (DCs) are a diverse group of specialized antigen-presenting cells with key roles in the initiation and regulation of innate and adaptive immune responses. As such, there is...
Engineering dendritic cell vaccines to improve cancer ...
2019年11月27日 · At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for cancer immunotherapy. Here...
Dendritic cell therapy in cancer treatment; the state-of-the ...
2020年8月1日 · In this review article, we first go through the immunobiology of DC, and development of DC vaccines. Then, we concentrate on the DC immunotherapy by highlighting combinational approaches to enhance the efficacy of cancer treatment strategies.
Cancer Immunotherapy Breakthrough: Dendritic Cell Vaccines
2022年1月24日 · A dendritic cell vaccine is a cross between a vaccine and a cell therapy. These dendritic cells are like immune system factories and make other molecules that activate critical parts of the innate and adaptive immune system.
Clinical use of dendritic cells for cancer therapy - The ...
2013年11月14日 · Since the mid-1990s, dendritic cells have been used in clinical trials as cellular mediators for therapeutic vaccination of patients with cancer. Dendritic cell-based immunotherapy is safe and can induce antitumour immunity, even in patients with advanced disease.
Recent Progress in Dendritic Cell-Based Cancer Immunotherapy
In this review, we first summarize the surface markers and functional properties of the five major DC subsets. We then describe new approaches to induce antigen-specific CTLs by targeted delivery of antigens to cross-presenting DCs.