STING agonist diABZI enhances the cytotoxicity of T cell ... - Nature
2024年4月13日 · Our findings revealed that diABZI enhanced the immunotherapy efficacy of TCR-T by activating STING media and TCR signaling pathways, improving interferon-γ expression, and increasing antigens...
A diamidobenzimidazole STING agonist protects against SARS …
2021年5月28日 · Here, we describe a diamidobenzimidazole compound, diABZI-4, that activates stimulator of interferon genes (STING) and is highly effective in limiting SARS-CoV-2 replication in cells and animals. diABZI-4 inhibited SARS-CoV-2 replication in lung epithelial cells.
Front Immunol 综述︱张翱团队总结STING信号通路在新冠中的作 …
目前已报道可抑制sars-cov-2感染和复制的sting激动剂主要为diabzi及其类似物，在多种模型，包括多种表达hace2的肿瘤细胞模型、胚胎干细胞诱导的肺泡模型以及k18-hace2转基因小鼠模型中均可抑制sars-cov-2感染和复制。
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 ...
2021年5月5日 · Here we describe a diamidobenzimidazole compound, diABZI-4, that activates STING and is highly effective in limiting SARS-CoV-2 replication in cells and animals. diABZI-4 inhibited SARS-CoV-2 replication in lung epithelial cells.
We show that airway application of STING agonists triggered a neutrophilic response in the bronchoalveolar space, induced cell death with the loss of epithelial barrier function and release of...
diABZI (compound 3) | STING agonist - InvivoGen
diABZI, diABZI (compound 3) trihydrochloride, is a novel non-nucleotide-based ligand that potently activates STING. Functionally validated. Water-soluble. Highest purity.
STING agonist diABZI induces PANoptosis and DNA mediated …
2022年3月25日 · A low dose of diABZI (1 µg by endotracheal route for 3 consecutive days) triggered an acute neutrophilic inflammation, disruption of the respiratory barrier, DNA release with NET formation ...
Total tanshinones ameliorates cGAS-STING-mediated …
2024年8月15日 · We first examined the effect of TTN on P65 nuclear translocation using immunofluorescence. P65 gradually translocated into the nucleus following diABZI activation of the cGAS-STING pathway, and TTN was able to inhibit this tendency (Fig. 3A).
STING agonist diABZI induces PANoptosis and DNA mediated …
We show that airway application of STING agonists triggered a neutrophilic response in the bronchoalveolar space, induced cell death with the loss of epithelial barrier function and release of self-dsDNA, neutrophil extracellular traps (NETs), and lung inflammation.
Increased activation of cGAS‐STING pathway enhances …
2022年4月15日 · Our findings indicate that diABZI may be a promising radiosensitizer for NSCLC cells, and further studies should be directed towards the influence of diABZI on the radiosensitivity of NSCLC cells in vivo to provide strong support for this conclusion.