Diazepam | C16H13ClN2O | CID 3016 - PubChem
Diazepam is a 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5. It has a role as a xenobiotic, an environmental contaminant, …
1,4-Benzodiazepines: Chemical stability and ... - ScienceDirect
2021年12月1日 · But most benzodiazepines are lipophilic with low pKa and, thus, their solubility at neutral and basic pH is generally below 0.1 mg/ml. Fig. 7 shows pH-solubility profiles of three different benzodiazepines in water at room temperature, diazepam (solubility 0.06 mg/ml at pH ≥ 6), midazolam (solubility 0.03 mg/ml at pH ≥ 7) and triazolam ...
Diazepam hydrochloride - DrugBank Online
Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect 7.
Benzodiazepines · Part One - LITFL
2019年7月18日 · Benzodiazepines are double-ringed positive allosteric modulators of the GABA receptors in the CNS. They: Activation increases Cl- conductance via increasing frequency of channel opening. Activation increases K+ conductance. Generally active metabolites. Renal elimination of active and inactive metabolites. ↓ V T, ↑ RR, apnoea.
A Physiologically Based Pharmacokinetic Model for Predicting Diazepam …
Our diazepam PBPK model successfully predicted diazepam PK in the adult population after doses administered through IV, oral, intranasal, and rectal routes. The non-oral routes for diazepam administration are preferred in an ambulatory setting, especially as the IV route in seizing patients is not convenient in an outpatient setting and as it ...
Diazepam - 439-14-5, C16H13ClN2O, density, melting
2024年4月29日 · Diazepam - cas 439-14-5, synthesis, structure, density, melting point, boiling point
Diazepam differs from oxazepam in that only one pKa has been ob- served in the normal pH region (3). The pKa of 3.3 is reportedly due to protonation at the azomethine nitrogen in the 4-position. Due to the methyl substitution on the amide nitrogen, the higher pKa observed with oxazepam, attributable to deprotonation of the amide proton, is absent.
Effect of Primary Packaging Material on the Stability …
Diazepam showed a better stability profile than midazolam, with the latter solubilised as a hydrochloride salt in an acidic pH that can affect the integrity of the elastomer over time.
Interpretation of Oral Fluid Tests for Drugs of Abuse - PMC
pKa: negative logarithm of equilibrium coefficient of neutral and charged forms of a compound. pKa is a constant for each drug. For basic compounds, those with higher pKa constants exhibit greater ionization in plasma (pH 7.4) than drugs with lower pKa constants.
Application of chemometrics in determination of the acid …
2015年3月10日 · In this study, the acid dissociation constants (p Ka) of some benzodiazepine derivatives including chlordiazepoxide, clonazepam, lorazepam, and oxazepam in aqueous micellar solution were determined spectrophotometrically at an ionic strength of 0.1 M at 25 °C.