Norcyclizine | C17H20N2 | CID 70048 - PubChem
1-Benzhydrylpiperazine is a known human metabolite of cinnarizine. Pictograms displayed are for 98% (50 of 51) of reports that indicate hazard statements. This chemical does not meet GHS hazard criteria for 2% (1 of 51) of reports. H302 (94.1%): Harmful if …
Cyclizine | C18H22N2 | CID 6726 - PubChem
Cyclizine is an N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group. It has a role as an antiemetic, a cholinergic antagonist, a central nervous system depressant, a local anaesthetic and a H1-receptor antagonist.
Cyclizine - an overview | ScienceDirect Topics
Cyclizine is a first-generation antihistamine, a piperazine derivative, with sedative and antimuscarinic activity, although its sedative effects are not marked. Cyclizine, 1- (diphenylmethyl)-4-methylpiperazine (16.1.15), is synthesized by alkylating 1-methylpiperazine with benzhydrylbromide [25, 26].
Cyclizine: Uses, Interactions, Mechanism of Action - DrugBank …
2005年6月13日 · Cyclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Cyclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness.
WO2018002696A1 - An improved process for the ... - Google Patents
In a preferred embodiment, the present invention provides an improved process for preparing Cyclizine which comprises methylating amine of Formula I i.e DPMP (benzhydryl piperazine) with...
Piperazine Derivatives - DrugBank Online
Chlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can... An antihistamine indicated in the treatment and prevention of allergic symptoms.
Synthesis of benzimidazoles containing piperazine ring as …
2024年5月15日 · By measuring a substance's ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, spectrophotometry is typically used to establish its antioxidant potential. The DPPH radical model is the most widely used method for fast evaluation of organic compounds' free radical scavenging ability.
Diphenyl piperazine derivatives possess broad pharmacological action on central nerves system (CNS), especially on dopaminergic neurotransmission [3].
PIPERAZINE – A BIOLOGICALLY ACTIVE SCAFFOLD
2015年10月1日 · This review would take on benzylpiperazine (BZP) and trifluoromethylpiperazine (TFMPP), benzhydryl piperazine, diphenylalkyl piperazine, phenyl piperazine as the most popular member of the...
Piperazine scaffold: A remarkable tool in generation of diverse ...
2015年9月18日 · Piperazine is one of the most sought heterocyclics for the development of new drug candidates. This ring can be traced in a number of well established, commercially available drugs. Wide array of pharmacological activities exhibited by piperazine derivatives have made them indispensable anchors for the development of novel therapeutic agents.
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