Diphtheria toxin - Wikipedia
Diphtheria toxin is an exotoxin secreted mainly by Corynebacterium diphtheriae but also by Corynebacterium ulcerans and Corynebacterium pseudotuberculosis, the pathogenic bacterium that causes diphtheria.
Diphtheria Toxin - an overview | ScienceDirect Topics
Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae and causes disease in humans by inhibiting protein synthesis. It enters the cell via the endosomal pathway [ Murphy, 2011 ], a feature shared by many other A-B toxins, including botulinum, tetanus, and anthrax [ Collier & Young, 2003 ; Hoch et al., 1985 ; Koriazova & Montal ...
Corynebacterium Diphtheriae - Medical Microbiology - NCBI Bookshelf
Corynebacterium diphtheriae infects the nasopharynx or skin. Toxigenic strains secrete a potent exotoxin which may cause diphtheria. The symptoms of diphtheria include pharyngitis, fever, swelling of the neck or area surrounding the skin lesion. Diphtheritic lesions are covered by a pseudomembrane.
Diphtheria - StatPearls - NCBI Bookshelf
2024年2月26日 · Diphtheria is a toxin-mediated infection primarily caused by Corynebacterium diphtheriae, a member of the Corynebacterium species. This infectious disease is characterized by skin and mucosal infections, occasionally progressing to focal infection after bacteremia.
Chapter 7: Diphtheria | Pink Book | CDC - Centers for Disease …
2024年4月23日 · Diphtheria toxin causes the local and systemic manifestations of diphtheria. C. diphtheriae has four biotypes: gravis, intermedius, mitis, and belfanti. All biotypes can become toxigenic and cause severe disease. All isolates of C. diphtheriae should be tested for toxigenicity.
Diphtheria Toxin - an overview | ScienceDirect Topics
The major virulence factor is a 58 kDa exotoxin responsible for the systemic complications of diphtheria, notably for myocardial and neurologic toxicity. 37 This exotoxin is very effective, since one molecule introduced into a cell can kill it. The exotoxin gene (tox) is present on a family of corynephages hosted by some C. diphtheriae strains.
Diphtheria - Nature Reviews Disease Primers
2019年12月5日 · Systemic effects, such as myocarditis and neuropathy, which are associated with increased fatality risk, are due to diphtheria toxin, an exotoxin produced by the pathogen that inhibits protein...
Diphtheria Toxoid–, Tetanus Toxoid–, and Acellular …
2011年8月25日 · Diphtheria is an acute upper respiratory illness caused by Corynebacterium diphtheriae. C. diphtheriae is a minimally invasive gram-positive bacillus that is resistant to environmental change and whose virulence is mostly confined to the secretion of an exotoxin that inhibits protein synthesis in mammalian cells (MacGregor, 2010).
Biology and molecular epidemiology of diphtheria toxin and …
Diphtheria toxin (DT) is an extracellular protein of Corynebacterium diphtheriae that inhibits protein synthesis and kills susceptible cells. The gene that encodes DT (tox) is present in some corynephages, and DT is only produced by C. diphtheriae isolates that harbor tox+ phages.
Diphtheria Toxin - an overview | ScienceDirect Topics
Diphtheria is a severe infection caused by the exotoxin-producing Corynebacterium diphtheriae. This disease is characterized by psuedomembrane formation in the pharynx and swollen lymph nodes and can lead to life-threatening complications like myocarditis or polyneuritis [35] .