Extrachromosomal circular DNA - Wikipedia
Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA structure that was first discovered in 1964 by Alix Bassel and Yasuo Hotta. [1]
Extrachromosomal circular DNA: biogenesis, structure, functions …
2022年10月2日 · Emerging investigations demonstrate that eccDNAs serve as multifunctional molecules in various organisms during diversified biological processes, such as epigenetic remodeling, telomere trimming,...
What Is Extrachromosomal Circular DNA and What Does It Do?
2024年10月20日 · For many years, researchers have observed smaller lengths of DNA alongside the chromosomes that are organized in circular forms. Some of these particles, which have been referred to as extrachromosomal circular DNA (eccDNAs) or microDNAs, are typically small (<1 kb), gene-sparse, and non-amplified.
Extrachromosomal circular DNA: biogenesis, structure, functions …
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source of somatic rearrangements, contributing to ...
Comparative analysis of methodologies for detecting extrachromosomal …
2024年10月25日 · Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity.
Extrachromosomal Circular DNA: Category, Biogenesis, …
Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin.
Extrachromosomal Circular DNA (eccDNA): From Chaos to …
2022年1月5日 · Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA that is derived and free from chromosomes. It has a strong heterogeneity in sequence, length, and origin and has been identified in both normal and cancer cells.
Extrachromosomal circular DNA (eccDNA): from carcinogenesis …
2024年4月25日 · Extrachromosomal circular DNA (eccDNA) is a circular form of DNA that exists outside of the chromosome. Although it has only been a few decades since its discovery, in recent years, it has been found to have a close relationship with cancer, which has attracted widespread attention from researchers.
Extrachromosomal circular DNA and structural variants ... - Nature
2023年8月28日 · Abundant extrachromosomal circular DNA (eccDNA) is associated with transposable element (TE) activity. However, how the eccDNA compartment is controlled by epigenetic regulations and what is its...
Extrachromosomal circular DNA: Current status and future …
2022年10月18日 · In this review, we first summarize the formation of eccDNA and its modes of action in eukaryotic cells. We then outline eccDNA as a disease biomarker and reveal its regulatory mechanism. We finally discuss the future prospects of eccDNA, including basic research and clinical application.