The genetic manipulation of non-model flatworms and its …
Second, I introduce a comprehensive toolkit for live imaging of whole-body regeneration in the flatworm Macrostomum lignano, including a high throughput cloning pipeline, a refined injection protocol, and several advanced microscopy techniques. By driving tissue-specific reporter expression, we examine how various structures regenerate.
Researchers work to genetically modify flatworms, understand …
2019年5月3日 · No one knows exactly how flatworms can rebuild their entire bodies from the tiniest sliver. Now, bioengineers and materials scientists are building new tools to study the worms’ awesome regenerative powers.
An entire flatworm regenerated from a single adult cell
2011年5月12日 · In a lab in MIT, a flatworm is dying. It’s a planarian – a simple animal that is normally very difficult to kill. Planarians are masters of regeneration; whole animals can be reborn from small...
The Cellular and Molecular Basis for Planarian Regeneration
Planarians are flatworms capable of dramatic feats of regeneration, which have been studied for over 2 centuries. Recent findings identify key cellular and molecular principles underlying these feats.
Regenerative Tissue Remodeling in Planarians – The Mysteries of ...
Biologists have long marveled at the ability of planarian flatworms to regenerate any parts of their bodies in just a little over a week. While great progress has been made in deciphering the mechanisms by which new tissue is formed at sites of amputation, we know relatively little about the complementary remodeling response that occurs in ...
Evolutionary dynamics of whole-body regeneration across planarian flatworms
2023年10月19日 · Even amongst planarian flatworms, well-known for complete regeneration from tiny body fragments, some species have restricted regeneration abilities while others are almost entirely regeneration...
Flatworm stem cells and the germ line: Developmental and …
2008年7月1日 · Here we describe the cloning and characterization of the flatworm Macrostomum lignano vasa-related gene macvasa and its use as a tool for answering questions concerning germ line formation. We show that macvasa mRNA and protein is expressed in male and female gonads and in somatic stem cells in juvenile and adult worms.
Random Integration Transgenesis in a Free-Living Regenerative Flatworm …
Here we describe a detailed protocol to create stable transgenic lines of the flatworm M. lignano using random integration of DNA constructs through microinjection into single-cell stage embryos.
Growing New Tissues: Unraveling Flatworm Regeneration
2009年7月24日 · Planarian flatworms are only a few millimeters up to a few centimeters in length, live in freshwater and are the object of intense research, because they possess the ability to regenerate...
The planarian flatworm Schmidtea mediterranea | Nature Methods
2023年1月12日 · Planaria are a group of worms within the phylum Platyhelminthes (flatworms). Many species, including Schmidtea mediterranea, have the ability to regenerate their body from small pieces of...
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