Growth Hormone Deficiency and Excess Alter the Gut …
2020年2月26日 · Emerging evidence suggests a link between the gut microbiome and the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis. That is, several studies point to microbial regulation of bone and linear growth by altering IGF-1 levels .
Growth Hormone Deficiency and Excess Alter the Gut …
2020年4月1日 · Our study thus characterized the adult gut microbial profile and intestinal phenotype in GH gene-disrupted (GH-/-) mice (a model of GH deficiency) and bovine GH transgenic (bGH) mice (a model of chronic, excess GH action) at 6 months of age.
Crosstalk between the growth hormone/insulin-like growth …
2020年8月1日 · Both the GH/IGF-axis and gut microbes are important for host growth and metabolism. Gut microbes impact growth partially through altering the GH/IGF-1 axis. IGF-1 normalizes the diversity of the microbial community in the gut. GH may alter microbes, microbial maturation, and short chain fatty acid production.
Excess Growth Hormone Alters the Male Mouse Gut Microbiome …
2022年5月25日 · Our study thus tracked the effect of excess GH action on the longitudinal changes in the gut microbial profile (ie, abundance, diversity/maturity, predictive metabolic function, and short-chain fatty acid [SCFA] levels) of bovine GH (bGH) transgenic mice at age 3, 6, and 12 months compared to littermate controls in the context of metabolism, int...
Crosstalk between the growth hormone/insulin-like growth …
Both the GH/IGF-1 axis and the gut microbiota independently play an important role in host growth, metabolism, and intestinal homeostasis.
SAT-281 Chronic, Excess Growth Hormone Action Alters the …
2020年5月8日 · That is, gut microbes impact growth by potentially altering the growth hormone (GH)/insulin-like growth factor-1 axis. Our previous research has also shown that GH - in states of absence and excess - is associated with altered gut microbial composition, maturity and predictive metabolic function in mice.
Impact of Growth Hormone on the Gut Microbiome
2020年2月26日 · The gut microbiome has been implicated in host metabolism, endocrinology, and pathophysiology. Furthermore, several studies have shown that gut bacteria impact host growth, partially mediated through the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis. Yet, no study to date has examined the specific role of GH on the gut microbiome.
Impact of different growth hormone levels on gut microbiota and ...
2024年4月6日 · The key message of our study is to identify human-relevant gut microbiota and host metabolic patterns that are interfered with growth hormone levels, and to develop biomarker models to identify...
Crosstalk between the growth hormone/insulin-like growth …
Both the GH/IGF-1 axis and the gut microbiota independently play an important role in host growth, metabolism, and intestinal homeostasis. Inversely, abnormalities in GH action and microbial dysbiosis (or a lack of diversity) in the gut have been implicated in restricted growth, metabolic disorders …
Multiple Effects of Growth Hormone in the Body: Is it Really the ...
In this review, we analyze the effects of growth hormone on a number of tissues and organs and its putative role in the longitudinal growth of an organism. We conclude that the hormone plays a very important role in maintaining the homogeneity of tissues and organs during the normal development of the human body or after an injury.