Glutamine - Gln - structure, properties, function, benefits
2024年7月23日 · Glutamine was first discovered by Schulze in 1883, who managed to isolate it from the beet juice. Later on, it turned out that glutamine can also be found in abundance in a wheat gliadin. Finally, in 1935, the synthesis of glutamine from ammonium and glutamate was explained and described by Krebs, who used the guinea pig and the rat kidney in ...
Glutamine synthetase - Wikipedia
Glutamine synthetase (GS) (EC 6.3.1.2) [3] is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine: Glutamate + ATP + NH 3 → Glutamine + ADP + phosphate
Structural Analysis of Glutamine Synthetase from - Nature
2018年8月3日 · Glutamine synthetase (GS) is an enzyme that regulates nitrogen metabolism and synthesizes glutamine via glutamate, ATP, and ammonia. GS is a homo-oligomeric protein of eight, ten, or twelve...
Structure–function relationships of glutamine synthetases
2000年3月7日 · As a highly regulated enzyme at the core of nitrogen metabolism, glutamine synthetase has been studied intensively. We review structural and functional studies of both bacterial and eukaryotic glutamine synthetases, with emphasis on enzymatic inhibitors.
Atomic structure of plant glutamine synthetase: a key enzyme
2006年9月29日 · Glutamine synthetase (GS), one of the essential enzymes for plant autotrophy catalyzes the incorporation of ammonia into glutamate to generate glutamine with concomitant hydrolysis of ATP, and plays a crucial role in the assimilation and re-assimilation of ammonia derived from a wide variety of metabolic processes during plant growth and ...
Structural Analysis of Glutamine Synthetase from Helicobacter …
Glutamine synthetase (GS) is an enzyme that regulates nitrogen metabolism and synthesizes glutamine via glutamate, ATP, and ammonia. GS is a homo-oligomeric protein of eight, ten, or twelve subunits, and each subunit-subunit interface has its own active site.
M. mazei glutamine synthetase and glutamine synthetase …
2023年11月15日 · Glutamine synthetases (GS) play central roles in cellular nitrogen assimilation. Although GS active-site formation requires the oligomerization of just two GS subunits, all GS form large,...
RCSB PDB - 2OJW: Crystal structure of human glutamine synthetase …
2007年1月15日 · Glutamine synthetase (GS) catalyzes the ligation of glutamate and ammonia to form glutamine, with concomitant hydrolysis of ATP. In mammals, the activity eliminates cytotoxic ammonia, at the same time converting neurotoxic glutamate to harmless glutamine; there are a number of links between changes in GS activity and neurodegenerative disorders ...
Crystal structure of N-terminal degron-truncated human glutamine synthetase
2021年11月11日 · Glutamine synthetase (GS) is a decameric enzyme that plays a key role in nitrogen metabolism. Acetylation of the N-terminal degron (N-degron) of GS is essential for ubiquitylation and subsequent GS degradation. The full-length GS structure showed that the N-degron is buried inside the GS decamer and is inaccessible to the acetyltransferase.
As a highly regulated enzyme at the core of nitrogen metabolism, glutamine synthetase has been studied intensively. We review structural and functional studies of both bacterial and eukaryotic glutamine synthetases, with emphasis on enzymatic