How ketamine affects three key regions of brain - Harvard Gazette
2023年5月31日 · Ketamine is the only one that induces the high-frequency gamma oscillations. At high doses, ketamine can induce general anesthesia — unconsciousness — but at low doses, it causes these antidepressant and dissociative effects. It’s a very unique and very important drug.
A Peek of How Ketamine Acts as ‘Switch’ in the Brain - Penn …
2022年12月1日 · Since its synthesis in the 1960s, ketamine has been a mainstay in anesthesia practice because of its reliable physiological effects and safety profile. One of ketamine’s signature characteristics is that it maintains some activity states across the surface of …
New Study Maps Ketamine's Effects on Brain - Columbia News
2023年12月4日 · Most studies of ketamine’s effects on the brain to-date have looked at the effects of acute exposure—how one dose affects the brain in the immediate term. For this study, researchers examined repeated daily exposure over the course of up to ten days.
Ketamine’s Effect on Brain Activity Revealed
2024年5月21日 · A new computational model reveals how ketamine, a widely used anesthetic and antidepressant, affects brain activity.
Brain region–specific action of ketamine as a rapid …
Collectively, these results reveal that ketamine blocks NMDARs in vivo in a brain region– and depression state–specific manner. The use-dependent nature of ketamine as an NMDAR blocker converges with local brain region properties to distinguish the LHb as a primary brain target of ketamine action.
Behind the Buzz: How Ketamine Changes the Depressed Patient's Brain
2019年4月12日 · Despite this excitement, researchers still don’t know exactly how ketamine exerts its effects. A leading theory proposes that it stimulates regrowth of synapses (connections between neurons),...
Characterizing brain dynamics during ketamine-induced ... - Nature
2023年3月29日 · Here, the authors analyzed ketamine-induced brain dynamics with intracranial recordings in humans and found that ketamine engages different brain areas in distinct frequency-dependent...
Study models how ketamine’s molecular action leads to its effects …
2024年6月4日 · New research addresses a gap in understanding how ketamine’s impact on individual neurons leads to pervasive and profound changes in brain network function. Ketamine is an important drug for anesthesia, pain control, sedation, and treating depression.
Region- and time- specific effects of ketamine on cerebral
2023年5月25日 · There is intriguing evidence suggesting that ketamine might have distinct acute and delayed neurofunctional effects, as its acute administration transiently induces schizophrenia-like symptoms,...
An integrative view on the cell-type-specific mechanisms of ketamine…
2024年1月13日 · Given that much of the research on cell-type-specific mechanisms that underlie the antidepressant effects of ketamine has focused on the PFC and hippocampus, we limit this review to the impact of ketamine on cells within these brain regions.