Knockout mouse - Wikipedia
A knockout mouse, or knock-out mouse, is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA.
Knockout Mice Fact Sheet - National Human Genome Research …
2020年8月17日 · A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA.
Knockout mouse | Genetic Engineering, Medical Research
knockout mouse, genetically engineered laboratory mouse (Mus musculus) in which a specific gene has been inactivated, or “knocked out,” by the introduction of a foreign (artificial) DNA sequence. Knockout mice exhibit modifications in phenotype (observable traits) and thereby provide important clues about the function of individual genes.
Knockout Mouse Project (KOMP) - The Jackson Laboratory
The Knockout Mouse Project (KOMP) is providing critical tools for understanding gene function and the genetic causes of human diseases. Coordinated by the International Mouse Phenotyping Consortium (IMPC), an international coalition will produce and phenotype a total of 5,000 knockout mice by 2016.
The Knockout Mouse Project (KOMP) - National Human Genome …
2012年6月15日 · The Knockout Mouse Project (KOMP) is a trans-National Institutes of Health (NIH) initiative that aims to generate a comprehensive and public resource comprised of mice containing a null mutation in every gene in the mouse genome.
基因敲除小鼠 - 百度百科
基因敲除小鼠（knockout mouse）是80年代后半期应用DNA同源重组原理发展起来的动物实验，其实小鼠有很多种，小白鼠只是其中一种，通常普通的小白鼠多被药厂用作临床试验，而基因敲除的小鼠，则用于更尖端的生物医学研究。
Knockout Mice - An Efficient Tool for Gene Function Research
2021年4月2日 · A knockout (KO) mouse is a genetically engineered animal model in which certain genes or DNA sequences have been deleted, thus achieving a nonfunctional gene which provides insights on its function. Investigating gene knockout mice characteristics can help scientists have a better understanding of gene functions and advance human disease research.
Knockout Mouse Phenotyping Project (KOMP2) - National …
2024年7月18日 · Design, produce and systematically phenotype a null mutation mouse line across the mouse–human orthologous genome to provide insights into gene function, disease genetics, pleiotropy and co-morbidity. KOMP2 and IMPC …
The Knockout Mouse Project - Nature Genetics
2004年9月1日 · Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling...
The Knockout Mouse Project - PMC
This project, tentatively named the Knockout Mouse Project (KOMP), will be a crucial step in harnessing the power of the genome to drive biomedical discovery. By creating a publicly available resource of knockout mice and phenotypic data, KOMP will knock down barriers for biologists to use mouse genetics in their research.