LILRB4 Gene - GeneCards | LIRB4 Protein | LIRB4 Antibody
6 days ago · LILRB4 (Leukocyte Immunoglobulin Like Receptor B4) is a Protein Coding gene. Diseases associated with LILRB4 include Myeloid Leukemia and Leukemia. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and …
LILRB4, an immune checkpoint on myeloid cells - PMC
Leukocyte immunoglobulin-like receptor B4 (LILRB4) is an inhibitory receptor in the LILR family mainly expressed on normal and malignant human cells of myeloid origin.
Leukocyte immunoglobulin‐like receptor B4: A keystone in …
Leukocyte immunoglobulin‐like receptor B4 (LILRB4) significantly impacts immune regulation and the pathogenesis and progression of various cancers. This review discusses LILRB4's structural attributes, expression patterns in immune cells, and molecular mechanisms in …
LILRB4 ITIMs mediate the T cell suppression and infiltration of acute ...
Nov 7, 2019 · We recently demonstrated that leukocyte Ig-like receptor 4 (LILRB4) expressed by monocytic acute myeloid leukemia (AML) cells mediates T-cell inhibition and leukemia cell infiltration via its...
LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism and …
In this review, we provide a comprehensive overview of LILRB4, encompassing its structure, expression, and ligand molecules as well as its role as a tolerance receptor. By exploring the involvement of LILRB4 in various diseases, its significance in disease progression is emphasized.
LILRB4, an immune checkpoint on myeloid cells - PubMed
May 17, 2022 · Leukocyte immunoglobulin-like receptor B4 (LILRB4) is an inhibitory receptor in the LILR family mainly expressed on normal and malignant human cells of myeloid origin.
LILRB4 signalling in leukaemia cells mediates T cell ... - Nature
Oct 17, 2018 · Thus, LILRB4 orchestrates tumour invasion pathways in monocytic leukaemia cells by creating an immunosuppressive microenvironment. LILRB4 represents a compelling target for the treatment of...
LILRB4, from the immune system to the disease target
Jul 15, 2020 · Leukocyte immunoglobulin (Ig)-like receptor B4 (LILRB4) is a member of leukocyte Ig-like receptors (LILRs), which associate with membrane adaptors to signal through multiple cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
LILRB4 suppresses immunity in solid tumors and is a potential …
Jul 5, 2021 · These findings reveal that LILRB4 strongly suppresses tumor immunity in TME and that alleviating that suppression provides antitumor efficacy. Immune receptors expressed on TAMs are intriguing targets for tumor immunotherapy.
LILRB4 Is a Novel Target for KMT2A Rearranged Acute Leukemia
Nov 15, 2022 · In the current study, we evaluate the anti-leukemia function of anti-LILRB4 CAR-T cells against KMT2Ar ALL and lineage switch disease. Methods and results: We first analyzed the expression of LILRB4 on a panel of B-ALL cell lines by flow cytometry.
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