Lipid-polymer nanoparticles to probe the native-like ... - Nature
2024年8月30日 · Polymers can facilitate detergent-free extraction of membrane proteins into nanodiscs (e.g., SMALPs, DIBMALPs), incorporating both integral membrane proteins as well as co-extracted native...
Passive, active and endogenous organ-targeted lipid and polymer ...
2023年1月19日 · Lipid and polymer nanoparticles represent leading approaches for the clinical translation of genetic drugs. These systems circumnavigate biological barriers and facilitate the intracellular...
Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview …
2023年8月21日 · In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid polymer hybrid nanoparticles, focusing on their main physicochemical properties and therapeutic potential.
Polymeric Lipid Hybrid Nanoparticles (PLNs) as Emerging Drug …
Polymeric lipid hybrid nanoparticles (PLNs) are core–shell nanoparticles made up of a polymeric kernel and lipid/lipid–PEG shells that have the physical stability and biocompatibility of both polymeric nanoparticles and liposomes.
Lipid nanoparticles for mRNA delivery | Nature Reviews Materials
2021年8月10日 · In this Review, we briefly overview representative lipid nanoparticles used for mRNA delivery and describe key steps in the preclinical development of lipid nanoparticle–mRNA formulations,...
Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical ...
2019年5月1日 · This review article is an updated overview on lipid-polymer hybrid nanoparticles (LPHNs) including the various types of LPHNs polymers used in their preparation, various methods of preparation, their physiochemical, in-vitro and in-vivo evaluation parameters and their application in various delivery systems. LPHNs show a combined advantage of ...
Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, …
2021年6月28日 · Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of the COVID-19 mRNA vaccines, LNPs play a key role in effectively protecting and transporting mRNA to cells.
Lipid–polymer hybrid nanoparticles as a new generation …
2013年11月1日 · Lipid–polymer hybrid nanoparticles (LPNs) are core–shell nanoparticle structures comprising polymer cores and lipid/lipid–PEG shells, which exhibit complementary characteristics of both polymeric nanoparticles and liposomes, particularly in terms of their physical stability and biocompatibility.
Lipid–polymer hybrid nanoparticles as a next-generation drug …
Lipid–polymer hybrid nanoparticles (LPHNPs) are next-generation core–shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous.
Lipid–Polymer Hybrid Nanosystems: A Rational Fusion for ... - MDPI
2023年8月23日 · To overcome these limitations of PNPs and lipid nanoparticles, a new system called lipid–polymer hybrid nanoparticles (LPHNPs) has been developed owing to the biomimetic and biocompatible advantages of this strategy. LPHNPs take advantage of the benefits of both polymeric and lipid-based systems [12].